Trial reportJournal of assisted reproduction and genetics2016
The endometrial preparation for frozen-thawed euploid blastocyst transfer: a prospective randomized trial comparing clinical results from natural modified cycle and exogenous hormone stimulation with GnRH agonist.
Trial report in Journal of assisted reproduction and genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02378584 (The Clinical Results After Frozen-thawed Healthy Blastocyst Transfer in Natural Cycle Versus Cycle With Endometrial Preparation), which is not on this map. Cited by 28 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Clinical Results After Frozen-thawed Healthy Blastocyst Transfer in Natural Cycle Versus Cycle With Endometrial Preparation
Who cites it
28 citing papers in PubMed, 8 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Cycle regimens for endometrial preparation prior to frozen embryo transfer.The Cochrane database of systematic reviews · 2025Pooled it
- Two laser-assisted hatching methods of embryos in ART: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Pooled it
- Preparation of the Endometrium for Frozen Embryo Transfer: A Systematic Review.Frontiers in endocrinology · 2021Pooled it
- Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes.The Cochrane database of systematic reviews · 2020Pooled it
- Women Undergoing Hormonal Treatments for Infertility: A Systematic Review on Psychopathology and Newly Diagnosed Mood and Psychotic Disorders.Frontiers in psychiatry · 2020Pooled it
- Cycle regimens for frozen-thawed embryo transfer.The Cochrane database of systematic reviews · 2017Pooled it
- Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing assisted reproductive techniques.The Cochrane database of systematic reviews · 2017Pooled it
- Endometrial Preparation for Frozen-Thawed Embryo Transfer With or Without Pretreatment With GnRH Agonist: A Randomized Controlled Trial at Two Centers.Frontiers in endocrinology · 2021Trial
- HCG administration after endogenous LH rise negatively influences pregnancy rate in modified natural cycle for frozen-thawed euploid blastocyst transfer: a pilot study.Journal of assisted reproduction and genetics · 2018Trial
- Comparing endometrial preparation protocols and clinical outcomes: lessons learned from 3507 vitrified-warmed euploid transfers.Journal of assisted reproduction and genetics · 2026Article
- Euploidy rate and reproductive outcomes in embryos biopsied at days 5, 6, 7 and 8 of development: a multicenter study.Journal of assisted reproduction and genetics · 2025Observational
- Article
- To curette or not to curette; efficiency of oocyte retrieval technique.Archives of gynecology and obstetrics · 2022Article
- Endometrial preparation methods prior to frozen embryo transfer: A retrospective cohort study comparing true natural cycle, modified natural cycle and artificial cycle.Archives of gynecology and obstetrics · 2022Article
- Effect of chemotherapy on the uterus of young adult cancer survivors.F&S reports · 2022Article
- Effect of artificial cycle with or without GnRH-a pretreatment on pregnancy and neonatal outcomes in women with PCOS after frozen embryo transfer: a propensity score matching study.Reproductive biology and endocrinology : RB&E · 2022Article
- The impact of endometrial preparation for frozen embryo transfer on maternal and neonatal outcomes: a review.Reproductive biology and endocrinology : RB&E · 2022Review
- Day 5 vs day 6 single euploid blastocyst frozen embryo transfers: which variables do have an impact on the clinical pregnancy rates?Journal of assisted reproduction and genetics · 2022Article
- A comparison of the clinical effects of thinning and drilling on laser-assisted hatching.Lasers in medical science · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of the study was to evaluate two methods of endometrial preparation for frozen-thawed single euploid blastocyst transfer: modified natural and artificial cycle with GnRH-agonist pituitary suppression.
methodsIn this prospective, controlled randomized trial, a total of 236 patients undergoing infertility treatment were randomized in 1:1 ratio; 118 received a frozen-thawed single euploid blastocyst transfer in a modified natural cycle and 118 in an artificial cycle with GnRH-agonist pituitary suppression. In the artificial protocol, GnRH-agonist combined with estradiol valerate was administered. In the natural protocol, only final oocyte maturation was induced using human chorionic gonadotropin administration. The primary end-points were the clinical pregnancy and implantation rates; the secondary end-points were the cost-benefit in terms of drug cost and the number of visits and the woman psychological distress caused by the treatment.
resultsNo significant differences were found in clinical pregnancy, implantation, and miscarriage rates between protocols. The number of clinical and ultrasound controls and the number of laboratory dosages and venous samplings were similar in both study groups. No significant differences were found between the groups in the anxiety and depression values before the start of treatment, on the days of progesterone administration, the blastocyst transfer, and pregnancy test.
conclusionsThe findings of this study evidence that in case of frozen-thawed single euploid blastocyst transfer, both protocols are equally effective in terms of clinical outcomes, cost-benefit, and patient compliance. The choice of endometrial preparation protocol should be based on women menstrual and ovulatory characteristics or otherwise on patient need for cycle planning.
trial registrationwww.clinicaltrials.gov with number NCT02378584.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.