ArticleInternational journal of molecular medicine2016
GABA A receptor π subunit promotes apoptosis of HTR-8/SVneo trophoblastic cells: Implications in preeclampsia.
Article in International journal of molecular medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Context-dependent features of transcriptomic landscapes in pregnant mother-neonate dyads of preeclampsia.Clinical and experimental pediatrics · 2026Article
- Benzodiazepine use during an IVF cycle and its impacts on miscarriage and other pregnancy outcomes.Human reproduction open · 2026Article
- Loss of resilience contributes to detrusor underactivity in advanced age.Biogerontology · 2023Article
- Elevated GABRP expression is correlated to the excessive autophagy in intrahepatic cholestasis of pregnancy.Heliyon · 2023Article
- Placental ion channels: potential target of chemical exposure.Biology of reproduction · 2023Review
- Placental transcriptomic signatures of spontaneous preterm birth.American journal of obstetrics and gynecology · 2023Article
- Maternal Dietary Supplementation with γ-Aminobutyric Acid Alleviated Oxidative Stress in Gestating Sows and Their Offspring by Regulating GABRP.Animals : an open access journal from MDPI · 2022Article
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- The Emerging Roles of π Subunit-Containing GABAInternational journal of medical sciences · 2021Review
- Use of a human embryonic stem cell model to discover GABRP, WFDC2, VTCN1 and ACTC1 as markers of early first trimester human trophoblast.Molecular human reproduction · 2020Article
- Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice.International journal of obesity (2005) · 2020Article
- Long non-coding RNA RPAIN regulates the invasion and apoptosis of trophoblast cell lines via complement protein C1q.Oncotarget · 2017Article
- In Silico Prediction of Gamma-Aminobutyric Acid Type-A Receptors Using Novel Machine-Learning-Based SVM and GBDT Approaches.BioMed research international · 2016Article
- Gamma-aminobutyric acid (GABA) can affect physiological processes in preimplantation embryos via GABAReproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gamma-aminobutyric acid (GABA) functions primarily as an inhibitory neurotransmitter through its receptors in the mature central nervous system. The GABA type A receptor π subunit (GABRP) has been identified in the tissues of the reproductive system, particularly in the uterus. In addition, we have previously detected GABRP expression in both human and mouse placentas. To examine the role of GABRP in trophoblastic cell invasion, we constructed a pIRES2-GABRP-EGFP plasmid which was used for the transfection of a human placental cell line derived from first trimester extravillous trophoblasts (HTR-8/SVneo). The number of invaded cells was decreased by GABRP overexpression. Notably, the decrease in the invasive cell number may be due to the increased apoptosis of the HTR-8/SVneo cells following GABRP transfection, which was further confirmed by flow cytometry, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis. Based on the increased apoptosis of trophoblastic cells in pregnancies complicated by preeclampsia (PE) and the fact that GABRP promotes the apoptosis of trophoblastic cells, we hypothesized that GABRP expression is increased in the placental tissues from patients with PE compared with that in the normal groups and this hypothesis was confirmed by RT-qPCR and immunohistochemical analysis. Taken together, these findings imply that GABRP plays an important role in placentation and this pathway may be a promising molecular target for the development of novel therapeutic strategies for PE.
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