Evidence map›Paper›PMID 27220948›Full record

ArticleJournal of pain and symptom management2016

Quality of Life in Children With Advanced Cancer: A Report From the PediQUEST Study.

Abby R Rosenberg, Liliana Orellana, Christina Ullrich, Tammy Kang, J Russell Geyer, Chris Feudtner, Veronica Dussel, Joanne Wolfe

Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pain and symptom management, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03999957 (CALLiNGS Protocol), which is not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03999957 nacompletednot on this mapstarted 2018, after this paper: background citation

CALLiNGS Protocol: Care Across Locations Longitudinally in Navigation of Goals and Symptoms (Interdisciplinary Pediatric Telepalliative Consultations for Hospice Teams)

TypeinterventionalSponsorUniversity of NebraskaRan2018 to 2020Enrolled30ConditionsPalliative CareArmsTelehealth web conferencing
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.

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  8. Associations of Age, Gender, and Family Income with Quality of Life in Children With Advanced Cancer.Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses
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  9. More than meets the eye: The hidden burden of temporary feeding tubes on children and their families.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Abby R RosenbergSeattle Children's Hospital Cancer and Blood Disorders Center, Seattle, Washington, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; Treuman Katz Center for Pediatric Bioethics, Seattle Children's Research Institute, Seattle, Washington, USA.
Liliana OrellanaBiostatistics Unit, Faculty of Health, Deakin University, Geelong, Victoria, Australia.
Christina UllrichDepartment of Psychosocial Oncology and Palliative Care, Boston, Massachusetts, USA; Center for Outcomes and Policy Research, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Department of Medicine, Boston Children's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA.
Tammy KangDepartment of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
J Russell GeyerSeattle Children's Hospital Cancer and Blood Disorders Center, Seattle, Washington, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Chris FeudtnerDepartment of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Veronica DusselDepartment of Medicine, Boston Children's Hospital, Boston, Massachusetts, USA; Center for Research and Implementation in Palliative Care, Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.
Joanne WolfeDepartment of Psychosocial Oncology and Palliative Care, Boston, Massachusetts, USA; Center for Outcomes and Policy Research, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Department of Medicine, Boston Children's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA. Electronic address: joanne_wolfe@dfci.harvard.edu.
Center for Cancer and Blood Disorders · USDana-Farber Cancer Institute · USUniversity of Pennsylvania · USDeakin University · AUInstituto de Efectividad Clínica y Sanitaria · AR

Funding

NCCIH Supplement to NCATS/CTSA Program for KL2 Scholars - M. SoddersKL2TR002317 · NCATS · UNIVERSITY OF WASHINGTON · PI Christy Michelle McKinney · 2017 to 2026
$14.5M
Institute of Translational Health SciencesKL2TR000421 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$12.6M
Symptom Distress in Pediatric Hematopoietic Stem Cell Transplant RecipientsK23HL107452 · NHLBI · DANA-FARBER CANCER INST · PI ULLRICH, CHRISTINA K · 2011 to 2015
$713k
Improving Care for Children with Advanced CancerK07CA096746 · NCI · DANA-FARBER CANCER INSTITUTE · PI WOLFE, JOANNE · 2002 to 2006
$678k
NCATS NIH HHS KL2 TR000421NCATS NIH HHS KL2 TR002317NCI NIH HHS K07 CA096746NCI NIH HHS L40 CA170049NHLBI NIH HHS K23 HL107452
6 · The paper itself

Abstract

contextModifiable factors of health-related quality of life (HRQOL) are poorly described among children with advanced cancer. Symptom distress may be an important factor for intervention.

objectivesWe aimed to describe patient-reported HRQOL and its relationship to symptom distress.

methodsProspective, longitudinal data from the multicenter Pediatric Quality of Life and Symptoms Technology study included primarily patient-reported symptom distress and HRQOL, measured at most weekly with the Memorial Symptoms Assessment Scale and Pediatric Quality of Life inventory, respectively. Associations were evaluated using linear mixed-effects models adjusting for sex, age, cancer type, intervention arm, treatment intensity, and time since disease progression.

resultsOf 104 enrolled patients, 49% were female, 89% were white, and median age was 12.6 years. Nine hundred and twenty surveys were completed over nine months of follow-up (84% by patients). The median total Pediatric Quality of Life score was 74 (interquartile range 63-87) and was "poor/fair" (e.g., <70) 38% of the time. "Poor/fair" categories were highest in physical (53%) and school (48%) compared to emotional (24%) and social (16%) subscores. Thirteen of 24 symptoms were independently associated with reductions in overall or domain-specific HRQOL. Patients commonly reported distress from two or more symptoms, corresponding to larger HRQOL score reductions. Neither cancer type, time since progression, treatment intensity, sex, nor age was associated with HRQOL scores in multivariable models. Among 25 children completing surveys during the last 12 weeks of life, 11 distressing symptoms were associated with reductions in HRQOL.

conclusionSymptom distress is strongly associated with HRQOL. Future research should determine whether alleviating distressing symptoms improves HRQOL in children with advanced cancer.

Indexed as

NeoplasmsQuality of LifeAdolescentChildFemaleFollow-Up StudiesHumansLinear ModelsLongitudinal StudiesMaleMultivariate AnalysisPalliative CarePatient Reported Outcome MeasuresProspective StudiesStress, PsychologicalTerminal Careend of lifepalliative carepatient-reported outcomespediatric cancerQuality of lifesymptom distress

Identifiers

PMID27220948
PMCPMC4996729
OpenAlexW2279352006

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.