ArticleScientific reports2016
Fungal endophytes of Catharanthus roseus enhance vindoline content by modulating structural and regulatory genes related to terpenoid indole alkaloid biosynthesis.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56 citing papers in PubMed, 142 citations in OpenAlex.
- Combined Fungal Elicitor and Methyl Jasmonate Enhance Alkaloid Accumulation inPlants (Basel, Switzerland) · 2026Article
- Novel production of vinblastine by immobilized cultures of mutant strain of the endophytic Alternaria alternata.World journal of microbiology & biotechnology · 2026Article
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- Pharmacologically Important Metabolites from Viola spp and Role of Associated Endophytes in Reshaping its Metabolites Biosynthesis.Current microbiology · 2026Review
- Unravelling the fungal endomicrobiome of Picrorhiza kurrooa for increasing in-planta picroside biosynthesis using endophytic Trichoderma harzianum PKRF1.Environmental microbiome · 2026Article
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- Microbial elicitors to metabolic reprogramming: an integrative model of plant-microbe interactions.Frontiers in microbiology · 2026Review
- Dynamics of fungal endophytic communities in bilberry (Vaccinium myrtillus L.) fruits through development is shaped by host phenolic compounds.FEMS microbiology ecology · 2025Article
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- Cloning and functional verification ofPeerJ · 2025Article
- Detection of vinblastine and related bioactive compounds from culture extracts of endophytic fungi of Catharanthus roseus.World journal of microbiology & biotechnology · 2024Article
- Microbial allies: exploring fungal endophytes for biosynthesis of terpenoid indole alkaloids.Archives of microbiology · 2024Review
- Genome Characteristics of the Endophytic FungusJournal of fungi (Basel, Switzerland) · 2024Article
- Arbuscular mycorrhiza and plant growth promoting endophytes facilitates accumulation of saponin under moderate drought stress.Chinese herbal medicines · 2024Article
- Unraveling endophytic diversity in dioecious Siraitia grosvenorii: implications for mogroside production.Applied microbiology and biotechnology · 2024Article
- Plants and endophytes interaction: a "secret wedlock" for sustainable biosynthesis of pharmaceutically important secondary metabolites.Microbial cell factories · 2023Review
- Fungal Elicitation Enhances Vincristine and Vinblastine Yield in the Embryogenic Tissues ofPlants (Basel, Switzerland) · 2023Article
- Plants as the Extended Phenotype of Endophytes-The Actual Source of Bioactive Compounds.International journal of molecular sciences · 2023Review
- Vinca alkaloids as a potential cancer therapeutics: recent update and future challenges.3 Biotech · 2023Review
- Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Not much is known about the mechanism of endophyte-mediated induction of secondary metabolite production in Catharanthus roseus. In the present study two fungal endophytes, Curvularia sp. CATDLF5 and Choanephora infundibulifera CATDLF6 were isolated from the leaves of the plant that were found to enhance vindoline content by 229-403%. The isolated endophytes did not affect the primary metabolism of the plant as the maximum quantum efficiency of PSII, net CO2 assimilation, plant biomass and starch content of endophyte-inoculated plants was similar to endophyte-free control plants. Expression of terpenoid indole alkaloid (TIA) pathway genes, geraniol 10-hydroxylase (G10H), tryptophan decarboxylase (TDC), strictosidine synthase (STR), 16-hydoxytabersonine-O-methyltransferase (16OMT), desacetoxyvindoline-4-hydroxylase (D4H), deacetylvindoline-4-O-acetyltransferase (DAT) were upregulated in endophyte-inoculated plants. Endophyte inoculation upregulated the expression of the gene for transcriptional activator octadecanoid-responsive Catharanthus AP2-domain protein (ORCA3) and downregulated the expression of Cys2/His2-type zinc finger protein family transcriptional repressors (ZCTs). The gene for the vacuolar class III peroxidase (PRX1), responsible for coupling vindoline and catharanthine, was upregulated in endophyte-inoculated plants. These endophytes may enhance vindoline production by modulating the expression of key structural and regulatory genes of vindoline biosynthesis without affecting the primary metabolism of the host plant.
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