ArticleScientific reports2016
Open and closed evolutionary paths for drastic morphological changes, involving serial gene duplication, sub-functionalization, and selection.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- CRISPR/Cas9-Mediated Disruption of Duplicated Sizzled Genes Induces Twin-Tail-like Caudal Bifurcation in Goldfish (International journal of molecular sciences · 2026Article
- Exploring the origin of a unique mutant allele in twin-tail goldfish using CRISPR/Cas9 mutants.Scientific reports · 2024Article
- Effect of Dietary Probiotic Lactobacillus helveticus on Growth Performance, Antioxidant Levels, and Absorption of Essential Trace Elements in Goldfish (Carassius auratus).Probiotics and antimicrobial proteins · 2019Article
- Embryonic and postembryonic development of the ornamental twin-tail goldfish.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
- A novel allele of the goldfish chdB gene: Functional evaluation and evolutionary considerations.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2018Article
- TGF-β Family Signaling in Early Vertebrate Development.Cold Spring Harbor perspectives in biology · 2018Review
- An alternative evolutionary pathway for the twin-tail goldfish via szl gene mutation.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2018Article
- The Formation of the Goldfish-Like Fish Derived From Hybridization of Female Koi Carp × Male Blunt Snout Bream.Frontiers in genetics · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Twin-tail goldfish strains are examples of drastic morphological alterations that emerged through domestication. Although this mutation is known to be caused by deficiency of one of two duplicated chordin genes, it is unknown why equivalent mutations have not been observed in other domesticated fish species. Here, we compared the chordin gene morphant phenotypes of single-tail goldfish and common carp (close relatives, both of which underwent chordin gene duplication and domestication). Morpholino-induced knockdown depleted chordin gene expression in both species; however, while knockdown reproduced twin-tail morphology in single-tail goldfish, it had no effect on common carp morphology. This difference can be explained by the observation that expression patterns of the duplicated chordin genes overlap completely in common carp, but are sub-functionalized in goldfish. Our finding implies that goldfish drastic morphological changes might be enhanced by the subsequent occurrence of three different types of evolutionary event (duplication, sub-functionalization, and selection) in a certain order.
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