ArticleLeukemia2016
Inhibition of precursor B-cell malignancy progression by toll-like receptor ligand-induced immune responses.
Abstract readLetter
In one paragraph
Article in Leukemia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- A genomic and epigenomic lens into the biology of acute lymphoblastic leukaemia.Nature reviews. Cancer · 2026Review
- The gastrointestinal microbiome and constituent short-chain fatty acids: a narrative review of an underexplored axis in acute lymphoblastic leukemia.Gut pathogens · 2026Review
- Childhood B cell leukemia: Intercepting the paths to progression.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024Review
- Article
- Concepts in B cell acute lymphoblastic leukemia pathogenesis.Journal of leukocyte biology · 2024Review
- Age and ligand specificity influence the outcome of pathogen engagement on preleukemic and leukemic B-cell precursor populations.Blood advances · 2023Article
- Immune stress suppresses innate immune signaling in preleukemic precursor B-cells to provoke leukemia in predisposed mice.Nature communications · 2023Article
- Gut microbiome immaturity and childhood acute lymphoblastic leukaemia.Nature reviews. Cancer · 2023Review
- Transient Inhibition of the JAK/STAT Pathway Prevents B-ALL Development in Genetically Predisposed Mice.Cancer research · 2022Article
- Antibiotics in early life and childhood pre-B-ALL. Reasons to analyze a possible new piece in the puzzle.Discover oncology · 2022Review
- Article
- Infectious triggers and novel therapeutic opportunities in childhood B cell leukaemia.Nature reviews. Immunology · 2021Review
- Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis.Scientific reports · 2020Article
- Regulatory effect of Act1 on the BAFF pathway in B-cell malignancy.Oncology letters · 2019Article
- A causal mechanism for childhood acute lymphoblastic leukaemia.Nature reviews. Cancer · 2018Review
- Acute lymphoblastic leukemia with aleukemic prodrome: preleukemic dynamics and possible mechanisms of immunosurveillance.Haematologica · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 2 countries.
M FidanzaMichael Cuccione Childhood Cancer Research Program, Child and Family Research Institute, Vancouver, British Columbia, Canada.
A E SeifCenter for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
A DeMiccoCenter for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
N RolfMichael Cuccione Childhood Cancer Research Program, Child and Family Research Institute, Vancouver, British Columbia, Canada.
S JoMichael Cuccione Childhood Cancer Research Program, Child and Family Research Institute, Vancouver, British Columbia, Canada.
B YinCenter for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Y LiCenter for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
D M BarrettCenter for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
J Duque-AfonsoDepartment of Pathology, School of Medicine, Stanford University, Stanford, CA, USA.
M L ClearyDepartment of Pathology, School of Medicine, Stanford University, Stanford, CA, USA.
C H BassingCenter for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
S A GruppCenter for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
G S D ReidMichael Cuccione Childhood Cancer Research Program, Child and Family Research Institute, Vancouver, British Columbia, Canada.
Child and Family Research Institute · CAChildren's Hospital of Philadelphia · USUniversity of Pennsylvania · USStanford University · USCancer Research Institute · USUniversity of British Columbia · CA
Funding
UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 1985 to 2026
$222.3MSpectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1MTRAINING PROGRAM IN CELL AND MOLECULAR BIOLOGYT32GM007229 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 1985 to 2023
$14.0MUSE OF mTOR INHIBITORS IN B CELL LEUKEMIAR01CA102646 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI GRUPP, STEPHAN A. · 2005 to 2009
$1.6MMolecular Pathways in Suppression and Development of T Lineage LymphomasR01CA125195 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI BASSING, CRAIG H · 2007 to 2011
$1.6MDeterminants of Relapse Risk After BMT for ALLR01CA116660 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI GRUPP, STEPHAN A. · 2007 to 2011
$1.5MCyclin D3 and DNA double strand breaks: genome stability and lymphomagenesisF31CA177092 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DEMICCO, AMY · 2013 to 2015
$95kCIHR MOP-126122NCATS NIH HHS UL1 TR001085NCI NIH HHS F31 CA177092NCI NIH HHS P30 CA016520NCI NIH HHS R01 CA102646NCI NIH HHS R01 CA116660NCI NIH HHS R01 CA125195NIGMS NIH HHS T32 GM007229
Abstract
PubMed holds no abstract for this paper.
Indexed as
Gene Expression Regulation, LeukemicAnimalsBasic Helix-Loop-Helix ProteinsCore Binding Factor Alpha 2 SubunitDisease ProgressionETS Translocation Variant 6 ProteinHumansImmune SystemInflammationLigandsMiceMice, TransgenicNeutralization TestsPAX5 Transcription FactorPhenotypePre-B-Cell Leukemia Transcription Factor 1Basic Helix-Loop-Helix ProteinsCore Binding Factor Alpha 2 SubunitETS Translocation Variant 6 ProteinLigandsPax5 protein, mousePAX5 Transcription FactorPbx1 protein, mousePre-B-Cell Leukemia Transcription Factor 1Proto-Oncogene Proteins c-etsRepressor ProteinsRunx1 protein, mouseTcf3 protein, mouseToll-Like Receptors
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.