Evidence map›Paper›PMID 27220646›Full record

ArticleTrends in genetics : TIG2016

Fishing for Function in the Human Gene Pool.

Iros Barozzi, Axel Visel, Diane E Dickel

Open access · greenAbstract readComment
In one paragraph

Article in Trends in genetics : TIG, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Iros BarozziLawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Axel ViselLawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA; School of Natural Sciences, University of California, Merced, California, USA. Electronic address: avisel@lbl.gov.
Diane E DickelLawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address: dedickel@lbl.gov.
Lawrence Berkeley National Laboratory · USJoint Genome Institute · US

Funding

Generation of an In Vivo Human Genome Transcriptional Enhancer DatasetR01HG003988 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Len Alexander Pennacchio · 2006 to 2026
$24.1M
Center for Mammalian Regulatory GenomicsU54HG006997 · NHGRI · LUDWIG INSTITUTE FOR CANCER RES LTD · PI REN, BING · 2012 to 2016
$14.3M
Regulation of Cardiac Development in Health and DiseaseUM1HL098166 · NHLBI · HARVARD MEDICAL SCHOOL · PI PENNACCHIO, LEN ALEXANDER, PU, WILLIAM TSWENCHING · 2015 to 2019
$4.4M
Genome-Wide Resources for Transcriptional Enhancers Active in the Human HeartR24HL123879 · NHLBI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PENNACCHIO, LEN ALEXANDER, VISEL, AXEL · 2015 to 2019
$3.9M
Genomic, Transgenic and Knockout Resources for Craniofacial Enhancer StudiesU01DE024427 · NIDCR · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI VISEL, AXEL · 2014 to 2018
$3.7M
NHGRI NIH HHS R01 HG003988NHGRI NIH HHS U54 HG006997NHLBI NIH HHS R24 HL123879NHLBI NIH HHS UM1 HL098166NIDCR NIH HHS U01 DE024427
6 · The paper itself

Abstract

Identification and characterization of causal non-coding variants in human genomes is challenging and requires substantial experimental resources. A new study by Tehranchi et al. describes a cost-effective approach for accurate mapping of molecular quantitative trait loci (QTLs) from pooled samples, a powerful way to link disease-associated changes to molecular functions.

Indexed as

Genome, HumanChromosome MappingGene PoolGenetic Diseases, InbornGenetic VariationHumansPolymorphism, Single NucleotideQuantitative Trait LociRegulatory Sequences, Nucleic Acidcis-regulationGWASnon-coding DNAQTL

Identifiers

PMID27220646
PMCPMC4912909
OpenAlexW2399690319

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.