Evidence map›Paper›PMID 27220616›Full record

ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2016

Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis.

Hamid Salimi, Matthew D Cain, Robyn S Klein

Open access · bronzeAbstract readReview
In one paragraph

Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 126 citations in OpenAlex.

  1. Review
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  17. Extracellular Vesicles inInternational journal of molecular sciences · 2024
    Review
  18. Article
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  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hamid SalimiDepartment of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Matthew D CainDepartment of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Robyn S KleinDepartment of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA. rklein@dom.wustl.edu.
Washington University in St. Louis · US

Funding

West Nile Virus and host control of innate defensesU19AI083019 · NIAID · UNIVERSITY OF WASHINGTON · PI CLARK, EDWARD A · 2009 to 2018
$22.5M
Validating diffusion MRI biomarkers of inflammation and axon pathologies in EAEP01NS059560 · NINDS · WASHINGTON UNIVERSITY · PI SONG, SHENG-KWEI · 2008 to 2018
$11.3M
Neuroprotection and repair during West Nile Virus EncephalitisR01NS052632 · NINDS · WASHINGTON UNIVERSITY · PI KLEIN, ROBYN S. · 2005 to 2020
$5.0M
Research Program Award (R35 Clinical Trial Optional) - Dr. Robyn Klein NINDSR35NS122310 · NINDS · WASHINGTON UNIVERSITY · PI CAIN, MATTHEW D · 2021 to 2024
$3.7M
NIAID NIH HHS U19 AI083019NINDS NIH HHS P01 NS059560NINDS NIH HHS R01 NS052632NINDS NIH HHS R35 NS122310
6 · The paper itself

Abstract

Arboviruses are arthropod-borne viruses that exhibit worldwide distribution, contributing to systemic and neurologic infections in a variety of geographical locations. Arboviruses are transmitted to vertebral hosts during blood feedings by mosquitoes, ticks, biting flies, mites, and nits. While the majority of arboviral infections do not lead to neuroinvasive forms of disease, they are among the most severe infectious risks to the health of the human central nervous system. The neurologic diseases caused by arboviruses include meningitis, encephalitis, myelitis, encephalomyelitis, neuritis, and myositis in which virus- and immune-mediated injury may lead to severe, persisting neurologic deficits or death. Here we will review the major families of emerging arboviruses that cause neurologic infections, their neuropathogenesis and host neuroimmunologic responses, and current strategies for treatment and prevention of neurologic infections they cause.

Indexed as

AnimalsArbovirusesBrainDisease Models, AnimalEncephalitis, ArbovirusHumansImmunity, InnateMiceNeurogliaNeuronsArbovirusBlood-brain barrierInnate immunityViral encephalitis

Identifiers

PMID27220616
PMCPMC4965410
OpenAlexW2407738865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.