Evidence map›Paper›PMID 27220607›Full record

ArticleDiagnostic microbiology and infectious disease2016

Evaluation of urine pneumococcal antigen test performance among adults in Western Kenya.

Lee M Hampton, Godfrey Bigogo, Geofrey Jagero, Maria da Gloria Carvalho, Fabiana Pimenta, Muthoni Junghae, Robert F Breiman, Cynthia G Whitney, Daniel R Feikin, Laura M Conklin

Abstract readEvaluation Study
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lee M HamptonDivision of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA. Electronic address: lhampton@cdc.gov.
Godfrey BigogoKenya Medical Research Institute/Centers for Disease Control and Prevention, Kisumu, Kenya.
Geofrey JageroKenya Medical Research Institute/Centers for Disease Control and Prevention, Kisumu, Kenya.
Maria da Gloria CarvalhoDivision of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA.
Fabiana PimentaDivision of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA.
Muthoni JunghaeKenya Medical Research Institute/Centers for Disease Control and Prevention, Kisumu, Kenya.
Robert F BreimanKenya Medical Research Institute/Centers for Disease Control and Prevention, Kisumu, Kenya.
Cynthia G WhitneyDivision of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA.
Daniel R FeikinKenya Medical Research Institute/Centers for Disease Control and Prevention, Kisumu, Kenya.
Laura M ConklinDivision of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

When used in an area of rural western Kenya, the BinaxNOW® urine antigen test had a sensitivity of 67% (95% Confidence Interval [CI]: 43-85%) among 21 adults ≥15 years old with acute respiratory illnesses and pneumococcal bacteremia and a specificity of 98% (95% CI: 96-99%) among 660 adults ≥15 years old without fever or cough. The specificity of the test was not significantly affected by pneumococcal colonization, regardless of patients' HIV status, age, or sex. Use of the pneumococcal urine antigen test in clinical assessments of adults in Africa with acute respiratory illness is a viable option regardless of whether a patient is colonized by pneumococci, even among HIV-infected adults, although the moderate sensitivity of the urine antigen test indicates that the test is probably best used clinically as part of a panel with other tests that can detect pneumococci.

Indexed as

AdolescentAdultAfricaAgedAged, 80 and overAntigensAntigens, BacterialDiagnostic Tests, RoutineFemaleHumansImmunoassayKenyaMaleMiddle AgedPneumococcal InfectionsSensitivity and SpecificityAntigensAntigens, BacterialAfricaHIVKenyaNasopharyngeal colonizationPneumococcusStreptococcus pneumoniaeUrine pneumococcal antigen test

Identifiers

PMID27220607
PMCPMC9040033

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.