Evidence map›Paper›PMID 27220430›Full record

ArticleCellular and molecular life sciences : CMLS2016

Vitamin D interferes with glucocorticoid responsiveness in human peripheral blood mononuclear target cells.

Eva Kassi, Narjes Nasiri-Ansari, Eliana Spilioti, Vassiliki Kalotychou, Panagiota E Apostolou, Paraskevi Moutsatsou, Athanasios G Papavassiliou

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Neurobiology of stress · 2025
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Eva KassiDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75, M. Asias Street, 11527, Athens, Greece.
Narjes Nasiri-AnsariDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75, M. Asias Street, 11527, Athens, Greece.
Eliana SpiliotiDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75, M. Asias Street, 11527, Athens, Greece.
Vassiliki KalotychouFirst Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 'Laikon' General Hospital, 11527, Athens, Greece.
Panagiota E ApostolouCenter for Basic Research, Biomedical Research Foundation of the Academy of Athens, 11527, Athens, Greece.
Paraskevi MoutsatsouDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75, M. Asias Street, 11527, Athens, Greece.
Athanasios G PapavassiliouDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75, M. Asias Street, 11527, Athens, Greece. papavas@med.uoa.gr.
National and Kapodistrian University of Athens · GRBiomedical Research Foundation of the Academy of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucocorticoids (GCs) are widely used in the treatment of inflammatory and autoimmune diseases; however, patients are often resistant to GC effects. Current studies indicate that vitamin D reduces the risk or modifies the course of autoimmune diseases posing vitamin D supplementation as a prevention or therapeutic option. Herein, we investigated whether vitamin D can modify the response to GCs at the molecular level. To this end, peripheral blood mononuclear cells (PBMCs) were isolated from healthy vitamin D-deficient women and incubated with either the active metabolite 1,25(OH)

Indexed as

AdultBlotting, WesternCell NucleusGlucocorticoidsHistone DeacetylasesHumansLeukocytes, MononuclearMiddle AgedPhosphorylationPhosphoserineProtein TransportReal-Time Polymerase Chain ReactionReceptors, GlucocorticoidRNA, MessengerTacrolimus Binding Protein 5Tacrolimus Binding Proteinsglucocorticoid receptor alphaGlucocorticoidsHistone DeacetylasesPhosphoserineReceptors, GlucocorticoidRNA, MessengerTacrolimus Binding Protein 5Tacrolimus Binding ProteinsTranscription FactorsTSC22D3 protein, humanVitamin DGene regulationGlucocorticoid receptorGlucocorticoidsPeripheral blood mononuclear cellsPhosphorylationVitamin D

Identifiers

PMID27220430
PMCPMC11108367
OpenAlexW2405528509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.