ArticleMolecular endocrinology (Baltimore, Md.)2016
Reprogramming of the Epigenome by MLL1 Links Early-Life Environmental Exposures to Prostate Cancer Risk.
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Article in Molecular endocrinology (Baltimore, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
What it found
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Who cites it
52 citing papers in PubMed, 76 citations in OpenAlex.
- Intergenerational Effects of Neonicotinoid Thiacloprid in Murine Prostate Tissue Are Associated with Epigenetic Alterations in Homeobox Hox Genes.International journal of molecular sciences · 2026Article
- Multifaceted mechanisms by which environmental endocrine-disrupting chemicals promote cancer progression: crosstalk among carcinogenesis, immunity, and metabolic reprogramming: narrative mini-review.Frontiers in molecular biosciences · 2026Review
- Endocrine-disrupting chemicals as prostate carcinogens.Nature reviews. Urology · 2025Review
- Impact of Endocrine Disruptors on the Genitourinary Tract.Journal of xenobiotics · 2024Review
- Removal of contaminants of emerging concern by Wolffia arrhiza and Lemna minor depending on the process conditions, pollutants concentration, and matrix type.Scientific reports · 2024Article
- The role of histone post-translational modifications in cancer and cancer immunity: functions, mechanisms and therapeutic implications.Frontiers in immunology · 2024Review
- Multiple tissue-specific epigenetic alterations regulate persistent gene expression changes following developmental DES exposure in mouse reproductive tissues.Epigenetics · 2023Article
- Decoding the Influence of Obesity on Prostate Cancer and Its Transgenerational Impact.Nutrients · 2023Review
- Developmental reprogramming of myometrial stem cells by endocrine disruptor linking to risk of uterine fibroids.Cellular and molecular life sciences : CMLS · 2023Article
- Epigenetic Modulation of Inflammatory Pathways in Myometrial Stem Cells and Risk of Uterine Fibroids.International journal of molecular sciences · 2023Article
- Environmental estrogen exposures alter molecular signaling in immune cells that promote the development of childhood asthma.Molecular immunology · 2023Article
- Endocrine-Disrupting Chemicals and Disease Endpoints.International journal of molecular sciences · 2023Review
- Toxicoepigenetics and Environmental Health: Challenges and Opportunities.Chemical research in toxicology · 2022Review
- Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment.Endocrine reviews · 2022Review
- High-fat diet aggravates prenatal low-dose DEHP exposure induced spermatogenesis disorder: Characterization of testicular metabolic patterns in mouse offspring.Chemosphere · 2022Article
- Developmental toxicant exposures and sex-specific effects on epigenetic programming and cardiovascular health across generations.Environmental epigenetics · 2022Review
- Tissue and sex-specific programming of DNA methylation by perinatal lead exposure: implications for environmental epigenetics studies.Epigenetics · 2021Article
- Combined Effects of Different Endocrine-Disrupting Chemicals (EDCs) on Prostate Gland.International journal of environmental research and public health · 2021Review
- The roles of inducible chromatin and transcriptional memory in cellular defense system responses to redox-active pollutants.Free radical biology & medicine · 2021Review
- High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Quan WangCenter for Translational Cancer Research (Q.W., L.S.T., R.L.Y.W., C.L.W.), Institute of Biosciences and Technology, Texas A&M University System Health Science Center, and Department of Molecular and Cellular Biology (C.E.F., C.C., B.W.O.), Baylor College of Medicine, Houston, Texas 77030; Department of Environmental Health (M.M., J.C., S.-m.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45267; Department of Epigenetics and Molecular Carcinogenesis (J.S.), University of Texas MD Anderson Cancer Center, Smithville, Texas 78957; and Department of Biochemistry and Molecular Genetics (A.S.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Lindsey S TrevinoCenter for Translational Cancer Research (Q.W., L.S.T., R.L.Y.W., C.L.W.), Institute of Biosciences and Technology, Texas A&M University System Health Science Center, and Department of Molecular and Cellular Biology (C.E.F., C.C., B.W.O.), Baylor College of Medicine, Houston, Texas 77030; Department of Environmental Health (M.M., J.C., S.-m.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45267; Department of Epigenetics and Molecular Carcinogenesis (J.S.), University of Texas MD Anderson Cancer Center, Smithville, Texas 78957; and Department of Biochemistry and Molecular Genetics (A.S.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Rebecca Lee Yean WongCenter for Translational Cancer Research (Q.W., L.S.T., R.L.Y.W., C.L.W.), Institute of Biosciences and Technology, Texas A&M University System Health Science Center, and Department of Molecular and Cellular Biology (C.E.F., C.C., B.W.O.), Baylor College of Medicine, Houston, Texas 77030; Department of Environmental Health (M.M., J.C., S.-m.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45267; Department of Epigenetics and Molecular Carcinogenesis (J.S.), University of Texas MD Anderson Cancer Center, Smithville, Texas 78957; and Department of Biochemistry and Molecular Genetics (A.S.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Mario MedvedovicCenter for Translational Cancer Research (Q.W., L.S.T., R.L.Y.W., C.L.W.), Institute of Biosciences and Technology, Texas A&M University System Health Science Center, and Department of Molecular and Cellular Biology (C.E.F., C.C., B.W.O.), Baylor College of Medicine, Houston, Texas 77030; Department of Environmental Health (M.M., J.C., S.-m.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45267; Department of Epigenetics and Molecular Carcinogenesis (J.S.), University of Texas MD Anderson Cancer Center, Smithville, Texas 78957; and Department of Biochemistry and Molecular Genetics (A.S.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Jing ChenCenter for Translational Cancer Research (Q.W., L.S.T., R.L.Y.W., C.L.W.), Institute of Biosciences and Technology, Texas A&M University System Health Science Center, and Department of Molecular and Cellular Biology (C.E.F., C.C., B.W.O.), Baylor College of Medicine, Houston, Texas 77030; Department of Environmental Health (M.M., J.C., S.-m.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45267; Department of Epigenetics and Molecular Carcinogenesis (J.S.), University of Texas MD Anderson Cancer Center, Smithville, Texas 78957; and Department of Biochemistry and Molecular Genetics (A.S.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Shuk-Mei HoCenter for Translational Cancer Research (Q.W., L.S.T., R.L.Y.W., C.L.W.), Institute of Biosciences and Technology, Texas A&M University System Health Science Center, and Department of Molecular and Cellular Biology (C.E.F., C.C., B.W.O.), Baylor College of Medicine, Houston, Texas 77030; Department of Environmental Health (M.M., J.C., S.-m.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45267; Department of Epigenetics and Molecular Carcinogenesis (J.S.), University of Texas MD Anderson Cancer Center, Smithville, Texas 78957; and Department of Biochemistry and Molecular Genetics (A.S.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Jianjun ShenCenter for Translational Cancer Research (Q.W., L.S.T., R.L.Y.W., C.L.W.), Institute of Biosciences and Technology, Texas A&M University System Health Science Center, and Department of Molecular and Cellular Biology (C.E.F., C.C., B.W.O.), Baylor College of Medicine, Houston, Texas 77030; Department of Environmental Health (M.M., J.C., S.-m.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45267; Department of Epigenetics and Molecular Carcinogenesis (J.S.), University of Texas MD Anderson Cancer Center, Smithville, Texas 78957; and Department of Biochemistry and Molecular Genetics (A.S.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Charles E FouldsCenter for Translational Cancer Research (Q.W., L.S.T., R.L.Y.W., C.L.W.), Institute of Biosciences and Technology, Texas A&M University System Health Science Center, and Department of Molecular and Cellular Biology (C.E.F., C.C., B.W.O.), Baylor College of Medicine, Houston, Texas 77030; Department of Environmental Health (M.M., J.C., S.-m.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45267; Department of Epigenetics and Molecular Carcinogenesis (J.S.), University of Texas MD Anderson Cancer Center, Smithville, Texas 78957; and Department of Biochemistry and Molecular Genetics (A.S.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Cristian CoarfaCenter for Translational Cancer Research (Q.W., L.S.T., R.L.Y.W., C.L.W.), Institute of Biosciences and Technology, Texas A&M University System Health Science Center, and Department of Molecular and Cellular Biology (C.E.F., C.C., B.W.O.), Baylor College of Medicine, Houston, Texas 77030; Department of Environmental Health (M.M., J.C., S.-m.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45267; Department of Epigenetics and Molecular Carcinogenesis (J.S.), University of Texas MD Anderson Cancer Center, Smithville, Texas 78957; and Department of Biochemistry and Molecular Genetics (A.S.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Bert W O'MalleyCenter for Translational Cancer Research (Q.W., L.S.T., R.L.Y.W., C.L.W.), Institute of Biosciences and Technology, Texas A&M University System Health Science Center, and Department of Molecular and Cellular Biology (C.E.F., C.C., B.W.O.), Baylor College of Medicine, Houston, Texas 77030; Department of Environmental Health (M.M., J.C., S.-m.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45267; Department of Epigenetics and Molecular Carcinogenesis (J.S.), University of Texas MD Anderson Cancer Center, Smithville, Texas 78957; and Department of Biochemistry and Molecular Genetics (A.S.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Ali ShilatifardCenter for Translational Cancer Research (Q.W., L.S.T., R.L.Y.W., C.L.W.), Institute of Biosciences and Technology, Texas A&M University System Health Science Center, and Department of Molecular and Cellular Biology (C.E.F., C.C., B.W.O.), Baylor College of Medicine, Houston, Texas 77030; Department of Environmental Health (M.M., J.C., S.-m.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45267; Department of Epigenetics and Molecular Carcinogenesis (J.S.), University of Texas MD Anderson Cancer Center, Smithville, Texas 78957; and Department of Biochemistry and Molecular Genetics (A.S.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Cheryl L WalkerCenter for Translational Cancer Research (Q.W., L.S.T., R.L.Y.W., C.L.W.), Institute of Biosciences and Technology, Texas A&M University System Health Science Center, and Department of Molecular and Cellular Biology (C.E.F., C.C., B.W.O.), Baylor College of Medicine, Houston, Texas 77030; Department of Environmental Health (M.M., J.C., S.-m.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45267; Department of Epigenetics and Molecular Carcinogenesis (J.S.), University of Texas MD Anderson Cancer Center, Smithville, Texas 78957; and Department of Biochemistry and Molecular Genetics (A.S.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Baylor College of Medicine · USUniversity of Cincinnati Medical Center · USNorthwestern University · USTexas A&M University System · USThe University of Texas MD Anderson Cancer Center · US
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9MTumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9MREPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI YADAV, JAGJIT S · 1992 to 2022
$35.4MREPRODUCTIVE HORMONES: BIOLOGICAL AND MOLECULAR ACTIONSR01HD008188 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI DAVID M LONARD, JOHN P LYDON · 1985 to 2026
$16.3MEpigenetic Signatures of Developmental Reprogramming in Target and Surrogate TissuesU01ES026719 · NIEHS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI BARTOLOMEI, MARISA S., WALKER, CHERYL L. · 2016 to 2020
$3.4MTARGETED GENOMICS FACILITY COREP30ES023512 · NIEHS · TEXAS A&M AGRILIFE RESEARCH · PI DEUTZ, NICOLAAS E · 2014 to 2017
$3.3MEpigenetic Programmers Targeted During Developmental ReprogrammingR01ES023206 · NIEHS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI BEDFORD, MARK T., MANCINI, MICHAEL A. · 2013 to 2016
$2.3MDevelopmental Reprogramming of Prostate Carcinogenesis by BPARC2ES018789 · NIEHS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WALKER, CHERYL L. · 2009 to 2010
$1.9MDevelopmental Exposure to Low-dose Bisphenol A and Human Prostate Cancer SusceptiRC2ES018758 · NIEHS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HO, SHUK-MEI, PRINS, GAIL S · 2009 to 2010
$1.9MNCI NIH HHS P30 CA060553NCI NIH HHS P30 CA125123NICHD NIH HHS R01 HD008188NIEHS NIH HHS P30 ES006096NIEHS NIH HHS P30 ES023512NIEHS NIH HHS R01 ES023206NIEHS NIH HHS RC2 ES018758NIEHS NIH HHS RC2 ES018789NIEHS NIH HHS U01 ES026719
Abstract
Tissue and organ development is a time of exquisite sensitivity to environmental exposures, which can reprogram developing tissues to increase susceptibility to adult diseases, including cancer. In the developing prostate, even brief exposure to endocrine-disrupting chemicals (EDCs) can increase risk for developing cancer in adulthood, with disruption of the epigenome thought to play a key role in this developmental reprogramming. We find that EDC-induced nongenomic phosphoinositide 3-kinase; (PI3K) signaling engages the histone methyltransferase mixed-lineage leukemia 1 (MLL1), responsible for the histone H3 lysine 4 trimethylation (H3K4me3) active epigenetic mark, to increase cleavage and formation of active MLL1 dimers. In the developing prostate, EDC-induced MLL1 activation increased H3K4me3 at genes associated with prostate cancer, with increased H3K4me3 and elevated basal and hormone-induced expression of reprogrammed genes persisting into adulthood. These data identify a mechanism for MLL1 activation that is vulnerable to disruption by environmental exposures, and link MLL1 activation by EDCs to developmental reprogramming of genes involved in prostate cancer.
Indexed as
AnimalsBlotting, WesternChromatin ImmunoprecipitationDisease Models, AnimalDNA-Binding ProteinsEndocrine DisruptorsEnvironmental ExposureEpigenesis, GeneticHEK293 CellsHistone-Lysine N-MethyltransferaseHistonesHumansImmunohistochemistryMaleMCF-7 CellsMethyltransferasesDNA-Binding ProteinsDOT1L protein, humanEndocrine DisruptorsHistone-Lysine N-MethyltransferaseHistonesKMT2A protein, humanKMT2D protein, humanMethyltransferasesMyeloid-Lymphoid Leukemia ProteinNeoplasm ProteinsPhosphatidylinositol 3-KinasesRNA, Small Interfering
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