ArticlePloS one2016
Inhibition in the Human Auditory Cortex.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Paired Pulse Suppression and Prepulse Inhibition in Patients with Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder.Brain sciences · 2025Article
- Age and sex effects on paired-pulse suppression and prepulse inhibition of auditory evoked potentials.Frontiers in neuroscience · 2024Article
- Target Site of Prepulse Inhibition of the Trigeminal Blink Reflex in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- The Effects of Attention on the Syllable-Induced Prepulse Inhibition of the Startle Reflex and Cortical EEG Responses against Energetic or Informational Masking in Humans.Brain sciences · 2022Article
- Mechanisms of Long-Latency Paired Pulse Suppression: MEG Study.Brain topography · 2022Article
- Auditory change-related cortical response is associated with hypervigilance to pain in healthy volunteers.European journal of pain (London, England) · 2022Article
- Early Schizophrenia and Bipolar Disorder Patients Display Reduced Neural Prepulse Inhibition.Brain sciences · 2022Article
- Effects of Magnitude of Leading Stimulus on Prepulse Inhibition of Auditory Evoked Cerebral Responses: An Exploratory Study.Life (Basel, Switzerland) · 2021Article
- Cortico-cortical connectivity behind acoustic information transfer to mouse orbitofrontal cortex is sensitive to neuromodulation and displays local sensory gating: relevance in disorders with auditory hallucinations?Journal of psychiatry & neuroscience : JPN · 2021Article
- Suppression of Somatosensory Evoked Cortical Responses by Noxious Stimuli.Brain topography · 2019Article
- Long-latency suppression of auditory and somatosensory change-related cortical responses.PloS one · 2018Article
- GABAergic mechanisms involved in the prepulse inhibition of auditory evoked cortical responses in humans.PloS one · 2018Article
- New paradigm for auditory paired pulse suppression.PloS one · 2017Article
- Representation of amplified speech at cortical level in good and poor hearing aid performers.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
- Expression of concern · 2023-01-11Conflict of Interest ·
- Expression of concern
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite their indispensable roles in sensory processing, little is known about inhibitory interneurons in humans. Inhibitory postsynaptic potentials cannot be recorded non-invasively, at least in a pure form, in humans. We herein sought to clarify whether prepulse inhibition (PPI) in the auditory cortex reflected inhibition via interneurons using magnetoencephalography. An abrupt increase in sound pressure by 10 dB in a continuous sound was used to evoke the test response, and PPI was observed by inserting a weak (5 dB increase for 1 ms) prepulse. The time course of the inhibition evaluated by prepulses presented at 10-800 ms before the test stimulus showed at least two temporally distinct inhibitions peaking at approximately 20-60 and 600 ms that presumably reflected IPSPs by fast spiking, parvalbumin-positive cells and somatostatin-positive, Martinotti cells, respectively. In another experiment, we confirmed that the degree of the inhibition depended on the strength of the prepulse, but not on the amplitude of the prepulse-evoked cortical response, indicating that the prepulse-evoked excitatory response and prepulse-evoked inhibition reflected activation in two different pathways. Although many diseases such as schizophrenia may involve deficits in the inhibitory system, we do not have appropriate methods to evaluate them; therefore, the easy and non-invasive method described herein may be clinically useful.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.