Evidence map›Paper›PMID 27219005›Full record

ArticlePloS one2016

HIV Incidence and Predictors of Incident HIV among Men Who Have Sex with Men Attending a Sexual Health Clinic in Melbourne, Australia.

King T Cheung, Christopher K Fairley, Tim R H Read, Ian Denham, Glenda Fehler, Catriona S Bradshaw, Marcus Y Chen, Eric P F Chow

Abstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Review
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  8. Article
  9. Eligibility criteriaEpidemiology and infection · 2022
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  13. Observational
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  15. Trends and Risk Factors for Antimicrobial-ResistantAntimicrobial agents and chemotherapy · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

King T CheungMelbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia.
Christopher K FairleyMelbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia.
Tim R H ReadMelbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia.
Ian DenhamMelbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia.
Glenda FehlerMelbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia.
Catriona S BradshawMelbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia.
Marcus Y ChenMelbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia.
Eric P F ChowMelbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this study was to determine the risk factors for HIV infection and the incidence in men who have sex with men (MSM). It is important to identify subgroups of MSM in which preventive interventions such as pre-exposure prophylaxis (PrEP) offered at the time of their last negative test would be considered cost-effective.

methodsWe conducted a retrospective cohort study of MSM attending Melbourne Sexual Health Centre (MSHC) during 2007-2013 with at least two HIV tests within 12 months of each other. Demographic characteristics, sexual and other behaviours, and bacterial sexually transmitted infection (STI) diagnoses were extracted from the date of the last negative HIV test. HIV incidence rate (IR) per 100 person-years for each risk factor was calculated.

resultsOf the 13907 MSM who attended MSHC, 5256 MSM had at least two HIV tests and were eligible, contributing 6391 person-years follow-up. 81 new HIV diagnoses were identified within 12 months of an HIV negative test with an incidence of 1.3 (95% CI: 1.0-1.6) per 100 person-years. Significant associations with subsequent HIV infection were: rectal gonorrhea (HIV IR: 3.4 95% CI: 2.1-5.2), rectal chlamydia (HIV IR: 2.6 95% CI: 1.7-3.7), inconsistent condom use (HIV IR: 2.1 95% CI: 1.6-2.7), use of post-exposure prophylaxis (HIV IR: 2.3 95% CI: 1.7-3.1), and injecting drug use (HIV IR: 8.5 95% CI: 3.4-17.5).

conclusionThe incidence of HIV was above 2.0% in subgroups of MSM with specific characteristics at the last HIV negative test. PrEP is considered cost effective at this incidence and could potentially be used along with other preventive interventions for these individuals in more than half of the population.

Indexed as

AdultAustraliaChlamydia InfectionsDrug UsersGonorrheaHIV InfectionsHomosexuality, MaleHumansIncidenceMaleMiddle AgedPost-Exposure ProphylaxisPre-Exposure ProphylaxisRectal DiseasesRetrospective StudiesSexual Behavior

Identifiers

PMID27219005
PMCPMC4878753

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.