ArticleeLife2016
Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Common principles for odour coding across vertebrates and invertebrates.Nature reviews. Neuroscience · 2024Review
- Diverse memory paradigms inLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Learning with sparse reward in a gap junction network inspired by the insect mushroom body.PLoS computational biology · 2024Article
- Future avenues inLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Article
- Learning and memory using Drosophila melanogaster: a focus on advances made in the fifth decade of research.Genetics · 2023Article
- Article
- Structured sampling of olfactory input by the fly mushroom body.Current biology : CB · 2022Article
- Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- An optogenetics device with smartphone video capture to introduce neurotechnology and systems neuroscience to high school students.PloS one · 2022Article
- Article
- Juvenile hormone drives the maturation of spontaneous mushroom body neural activity and learned behavior.Neuron · 2021Article
- Transsynaptic mapping ofeLife · 2021Article
- Neural Circuits Underlying Behavioral Flexibility: Insights FromFrontiers in behavioral neuroscience · 2021Review
- Localized inhibition in theeLife · 2020Article
- Cellular and circuit mechanisms of olfactory associative learning inJournal of neurogenetics · 2020Review
- Astroglial connexins and cognition: memory formation or deterioration?Bioscience reports · 2020Review
- Article
- The neural circuit linking mushroom body parallel circuits induces memory consolidation inProceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gap junctions are widely distributed in the brains across species and play essential roles in neural information processing. However, the role of gap junctions in insect cognition remains poorly understood. Using a flight simulator paradigm and genetic tools, we found that gap junctions are present in Drosophila Kenyon cells (KCs), the major neurons of the mushroom bodies (MBs), and showed that they play an important role in visual learning and memory. Using a dye coupling approach, we determined the distribution of gap junctions in KCs. Furthermore, we identified a single pair of MB output neurons (MBONs) that possess a gap junction connection to KCs, and provide strong evidence that this connection is also required for visual learning and memory. Together, our results reveal gap junction networks in KCs and the KC-MBON circuit, and bring new insight into the synaptic network underlying fly's visual learning and memory.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.