Evidence map›Paper›PMID 27218435›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society2016

Late-onset severe pneumonia after allogeneic hematopoietic stem cell transplantation: prognostic factors and treatments.

X-D Mo, X-H Zhang, L-P Xu, Y Wang, C-H Yan, H Chen, Y-H Chen, W Han, F-R Wang, J-Z Wang and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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  7. [How I treat late-onset severe pneumonia after allogeneic stem cell transplantation].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2023
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  16. Late-onset severe pneumonia after allogeneic hematopoietic stem cell transplantation: prognostic factors and treatments.Transplant infectious disease : an official journal of the Transplantation Society · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

X-D MoPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
X-H ZhangPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
L-P XuPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Y WangPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
C-H YanPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
H ChenPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Y-H ChenPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
W HanPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
F-R WangPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
J-Z WangPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
K-Y LiuPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
X-J HuangPeking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Peking University · CNPeking University People's Hospital · CNCenter for Life Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this study, we aimed to evaluate the prognostic factors associated with and treatments for late-onset severe pneumonia (LOSP) in patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT).

methodsFifty consecutive patients who underwent non-T-cell-depleted allo-HSCT at the Peking University Institute of Hematology and met the criterion of LOSP after allo-HSCT were enrolled.

resultsThe median time from allo-HSCT to the occurrence of LOSP was 231 (90-1487) days. Twenty-eight patients harbored 1 or more pathogens (infectious LOSP, I-LOSP), whereas 22 did not harbor any pathogens (non-infectious LOSP, NI-LOSP). The 100-day survival rate of LOSP patients was 31.1%. Patients smoking before allo-HSCT (0% vs. 35.4%, P = 0.002) and male gender (20.0% vs. 61.9%, P = 0.026) had lower 100-day survival rate. Patients with a lower bronchoalveolar lavage fluid (BALF) neutrophil percentage had higher 100-day survival rate relative to those with higher BALF neutrophil percentage (45.5% vs. 16.7%, P = 0.012). The 100-day survival rate of patients with I-LOSP was lower than that of patients with NI-LOSP (19.1% vs. 46.9%, P = 0.043). Patients given late (≥1 week after LOSP diagnosis) and low-dose methylprednisolone (MP) therapy (≤2 mg/kg/day) had the best 100-day survival rate. In the multivariate analysis, nonsmoking before allo-HSCT and late and low-dose MP therapy were significantly associated with a better survival after LOSP.

conclusionLOSP is a severe complication after allo-HSCT. The correct timing and corticosteroid dosage in the context of broad-spectrum antimicrobial therapy might further improve the outcomes of patients with LOSP.

Indexed as

AdolescentAdultBronchoalveolar Lavage FluidFemaleFollow-Up StudiesGlucocorticoidsGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHLA AntigensHumansImmunosuppressive AgentsMaleMethylprednisoloneMiddle AgedPneumoniaPrognosisGlucocorticoidsHLA AntigensImmunosuppressive AgentsMethylprednisoloneallogeneic hematopoietic stem cell transplantationlate-onset severe pneumoniamethylprednisone

Identifiers

PMID27218435
PMCPMC7169772
OpenAlexW2405856165

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.