Evidence map›Paper›PMID 27218216›Full record

ArticleJournal of diabetes investigation2017

Elevated expression levels of serum insulin-like growth factor-1, tumor necrosis factor-α and vascular endothelial growth factor 165 might exacerbate type 2 diabetic nephropathy.

Xiang Li, Ting-Ting Wu, Juan Chen, Wen Qiu

Open access · goldAbstract read
In one paragraph

Article in Journal of diabetes investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 46 citations in OpenAlex.

  1. Quantification of vitreous VEGF-A121 and VEGF-A165 using an isoform-specific ELISA in proliferative diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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  11. miR-154-5p Affects the TGFOxidative medicine and cellular longevity · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Xiang LiDepartment of Clinical Laboratory, Huai'an Hospital Affiliated of Xuzhou Medical University, Huai'an, China.
Ting-Ting WuDepartment of Clinical Laboratory, The Fourth People's Hospital of Huai'an, Huai'an, China.
Juan ChenDepartment of Endocrinology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
Wen QiuDepartment of Clinical Laboratory, Huai'an Hospital Affiliated of Xuzhou Medical University, Huai'an, China.
Nanjing Medical University · CNSecond People’s Hospital of Huai’an · CNThe Fourth People's Hospital · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIMS/

introductionThe present study aimed to determine the associations between expressions of insulin-like growth factor-1 (IGF-1), tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor 165 (VEGF MATERIALS AND

methodsA total of 108 patients diagnosed as DN were randomly selected, including 50 patients in the microalbuminuria group, 44 patients in the macroalbuminuria group and 14 patients in the renal insufficiency group. Meanwhile, 97 healthy people were collected as a normal control group. Urinary albumin (UALB) and urine creatinine (Cr) of all participants were measured for 24 h, with their ratio (UALB/Cr) being calculated. Enzyme-linked immunosorbent assay was used to detect the serum concentrations of IGF-1, TNF-α and VEGF

resultsThe expressions of serum IGF-1, TNF-α and VEGF

conclusionsElevated expression levels of serum IGF-1, TNF-α and VEGF

Indexed as

Diabetes Mellitus, Type 2Diabetic NephropathiesFemaleHumansInsulin-Like Growth Factor IMaleMiddle AgedSeverity of Illness IndexTumor Necrosis Factor-alphaVascular Endothelial Growth Factor AInsulin-Like Growth Factor ITumor Necrosis Factor-alphaVascular Endothelial Growth Factor AVEGFA protein, humanInsulin-like growth factor-1Type 2 diabetic nephropathyVascular endothelial growth factor 165

Identifiers

PMID27218216
PMCPMC5217934
OpenAlexW2397342997

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.