ArticleTheranostics2016
Supramolecular Crafting of Self-Assembling Camptothecin Prodrugs with Enhanced Efficacy against Primary Cancer Cells.
Article in Theranostics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 66 citations in OpenAlex.
- Progress and Future Directions with Peptide-Drug Conjugates for Targeted Cancer Therapy.Molecules (Basel, Switzerland) · 2021Review
- The role of critical micellization concentration in efficacy and toxicity of supramolecular polymers.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Self-Assembly Nanoparticles for Overcoming Multidrug Resistance and Imaging-Guided Chemo-Photothermal Synergistic Cancer Therapy.International journal of nanomedicine · 2020Article
- Tumor-Specific Drug Release and Reactive Oxygen Species Generation for Cancer Chemo/Chemodynamic Combination Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Supramolecular Tuning of HBiomacromolecules · 2019Article
- Host-Guest Chemistry in Supramolecular Theranostics.Theranostics · 2019Review
- Supramolecular Nanotheranostics.Theranostics · 2019Article
- Redox-Responsive Dual Chemophotothermal Therapeutic Nanomedicine for Imaging-Guided Combinational Therapy.Journal of materials chemistry. B · 2018Article
- Hierarchical Tumor Microenvironment-Responsive Nanomedicine for Programmed Delivery of Chemotherapeutics.Advanced materials (Deerfield Beach, Fla.) · 2018Article
- Camptothecin inhibits the progression of NPC by regulating TGF-β-induced activation of the PI3K/AKT signaling pathway.Oncology letters · 2018Article
- Self-assembly behaviours of peptide-drug conjugates: influence of multiple factors on aggregate morphology and potential self-assembly mechanism.Royal Society open science · 2018Article
- Nanotherapeutic systems for local treatment of brain tumors.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2018Review
- Coarse-grained molecular dynamics studies of the structure and stability of peptide-based drug amphiphile filaments.Soft matter · 2017Article
- Self-assembling prodrugs.Chemical Society reviews · 2017Review
- Molecular design and synthesis of self-assembling camptothecin drug amphiphiles.Acta pharmacologica Sinica · 2017Article
- Peptide-drug conjugates as effective prodrug strategies for targeted delivery.Advanced drug delivery reviews · 2017Review
- One-Component Supramolecular Filament Hydrogels as Theranostic Label-Free Magnetic Resonance Imaging Agents.ACS nano · 2017Article
- Drug-Bearing Supramolecular Filament Hydrogels as Anti-Inflammatory Agents.Theranostics · 2017Article
- Antiproliferative activities of Amaryllidaceae alkaloids from Lycoris radiata targeting DNA topoisomerase I.Scientific reports · 2016Article
- Progress in the Development of Nanotheranostic Systems.Theranostics · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Chemical modification of small molecule hydrophobic drugs is a clinically proven strategy to devise prodrugs with enhanced treatment efficacy. While this prodrug strategy improves the parent drug's water solubility and pharmacokinetic profile, it typically compromises the drug's potency against cancer cells due to the retarded drug release rate and reduced cellular uptake efficiency. Here we report on the supramolecular design of self-assembling prodrugs (SAPD) with much improved water solubility while maintaining high potency against cancer cells. We found that camptothecin (CPT) prodrugs created by conjugating two CPT molecules onto a hydrophilic segment can associate into filamentous nanostructures in water. Our results suggest that these SAPD exhibit much greater efficacy against primary brain cancer cells relative to that of irinotecan, a clinically used CPT prodrug. We believe these findings open a new avenue for rational design of supramolecular prodrugs for cancer treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.