Evidence map›Paper›PMID 27217838›Full record

ArticleTheranostics2016

ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging.

Chenggen Qian, Yulei Chen, Sha Zhu, Jicheng Yu, Lei Zhang, Peijian Feng, Xin Tang, Quanyin Hu, Wujin Sun, Yue Lu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Enhancing immunotherapy with tumour-responsive nanomaterials.Nature reviews. Clinical oncology · 2025
    Review
  7. Review
  8. "Biomaterials translational · 2024
    Review
  9. Theranostic Diagnostics.Results and problems in cell differentiation · 2024
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Tumor microenvironment responsive drug delivery systems.Asian journal of pharmaceutical sciences · 2020
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Extremely long tumor retention, multi-responsive boronate crosslinked micelles with superior therapeutic efficacy for ovarian cancer.Journal of controlled release : official journal of the Controlled Release Society · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chenggen Qian1. Department of Polymer Science & Engineering and Key Laboratory of High Performance Polymer Materials & Technology of MOE, Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210023, China;; 2. Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA;; 3. Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;
Yulei Chen1. Department of Polymer Science & Engineering and Key Laboratory of High Performance Polymer Materials & Technology of MOE, Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210023, China;
Sha Zhu1. Department of Polymer Science & Engineering and Key Laboratory of High Performance Polymer Materials & Technology of MOE, Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210023, China;
Jicheng Yu2. Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA;; 3. Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;
Lei Zhang1. Department of Polymer Science & Engineering and Key Laboratory of High Performance Polymer Materials & Technology of MOE, Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210023, China;
Peijian Feng1. Department of Polymer Science & Engineering and Key Laboratory of High Performance Polymer Materials & Technology of MOE, Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210023, China;
Xin Tang1. Department of Polymer Science & Engineering and Key Laboratory of High Performance Polymer Materials & Technology of MOE, Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210023, China;
Quanyin Hu2. Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA;; 3. Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;
Wujin Sun2. Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA;; 3. Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;
Yue Lu2. Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA;; 3. Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;
Xuanzhong Xiao1. Department of Polymer Science & Engineering and Key Laboratory of High Performance Polymer Materials & Technology of MOE, Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210023, China;
Qun-Dong Shen1. Department of Polymer Science & Engineering and Key Laboratory of High Performance Polymer Materials & Technology of MOE, Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210023, China;
Zhen Gu2. Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA;; 3. Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;; 4. Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

Funding

North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
NCATS NIH HHS UL1 TR001111
6 · The paper itself

Abstract

Stimuli-responsive and imaging-guided drug delivery systems hold vast promise for enhancement of therapeutic efficacy. Here we report an adenosine-5'-triphosphate (ATP)-responsive and near-infrared (NIR)-emissive conjugated polymer-based nanocarrier for the controlled release of anticancer drugs and real-time imaging. We demonstrate that the conjugated polymeric nanocarriers functionalized with phenylboronic acid tags on surface as binding sites for ATP could be converted to the water-soluble conjugated polyelectrolytes in an ATP-rich environment, which promotes the disassembly of the drug carrier and subsequent release of the cargo. In vivo studies validate that this formulation exhibits promising capability for inhibition of tumor growth. We also evaluate the metabolism process by monitoring the fluorescence signal of the conjugated polymer through the in vivo NIR imaging.

Indexed as

Adenosine TriphosphateAntineoplastic AgentsBoronic AcidsDoxorubicinDrug CarriersHep G2 CellsHumansLiver NeoplasmsNanoparticlesOptical ImagingTheranostic NanomedicineAdenosine TriphosphateAntineoplastic Agentsbenzeneboronic acidBoronic AcidsDoxorubicinDrug CarriersATP-responsiveconjugated polymers.drug deliverynanomedicinestimuli-responsivetheranostics

Identifiers

PMID27217838
PMCPMC4876629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.