Evidence map›Paper›PMID 27217717›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2016

Lack of association of the M129V polymorphism of the PRNP gene with pseudoexfoliation syndrome.

Marios P Giannakopoulos, Anna G Antonacopoulou, Anastasia E Kottorou, Haralabos P Kalofonos, Sotirios P Gartaganis

Open access · goldAbstract read
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In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Marios P GiannakopoulosDepartment of Ophthalmology, School of Medicine, University of Patras, Rion, Greece.
Anna G AntonacopoulouDepartment of Medicine, Molecular Oncology Laboratory, Division of Oncology, University of Patras, Rion, Greece.
Anastasia E KottorouDepartment of Medicine, Molecular Oncology Laboratory, Division of Oncology, University of Patras, Rion, Greece.
Haralabos P KalofonosDepartment of Medicine, Molecular Oncology Laboratory, Division of Oncology, University of Patras, Rion, Greece.
Sotirios P GartaganisDepartment of Ophthalmology, School of Medicine, University of Patras, Rion, Greece.
University of Patras · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn this study we aimed to evaluate the polymorphism at codon 129 (M129V) of the PRNP gene as a secondary risk factor for pseudoexfoliation syndrome (PEX).

methodsTwo hundred and seventy-five unrelated subjects, including 156 patients with PEX and 119 unrelated control subjects, were recruited from the University Hospital of Patras, Greece. All patients and controls were of Caucasian or European ancestry. The PRNP M129V (A/G) single-nucleotide polymorphism was genotyped by real-time polymerase chain reactions. Association of the polymorphism with PEX was assessed using the two-sided Pearson's chi-squared or Fisher's exact test.

resultNo significant difference between patients and controls was observed in terms of frequencies of alleles and genotypes of the PRNP gene.

conclusionPolymorphism at M129V of the PRNP gene was evaluated as a secondary risk factor for developing PEX. Our results suggest that this PRNP gene polymorphism is not associated with PEX.

Indexed as

M129VPEXpolymorphismprotein folding disorderspseudoexfoliation syndrome

Identifiers

PMID27217717
PMCPMC4853150
OpenAlexW2343023805

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