SynthesisAnnals of oncology : official journal of the European Society for Medical Oncology2016
Oral health and risk of colorectal cancer: results from three cohort studies and a meta-analysis.
Synthesis in Annals of oncology : official journal of the European Society for Medical Oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 5 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Associations of oral health with colorectal cancer risk: accumulated evidences from observational studies.BMC cancer · 2026Pooled it
- Causal association between periodontitis and systemic diseases: a systematic review and meta-analysis of mendelian randomization studies.BMC oral health · 2026Pooled it
- Pooled it
- Hematopoietic and lymphatic cancers in patients with periodontitis: a systematic review and meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2020Pooled it
- Periodontal Disease, Tooth Loss, and Cancer Risk.Epidemiologic reviews · 2017Pooled it
- Red Complex Periodontal Pathogens and Their Potential Role in Colorectal Carcinogenesis: A Narrative Review.International journal of molecular sciences · 2025Review
- Association between periodontitis and gastrointestinal cancer risk and prognosis: evidence from a nested case-control study in Southwest China.European journal of medical research · 2025Article
- Relationship between periodontitis and systemic health conditions: a narrative review.Ewha medical journal · 2025Review
- Evaluation of Periodontitis andHealthcare (Basel, Switzerland) · 2024Article
- The Oral Microbiome as Mediator between Oral Hygiene and Its Impact on Nasopharyngeal Carcinoma.Microorganisms · 2023Article
- Tooth Loss and Risk of Lung Cancer among Urban Chinese Adults: A Cohort Study with Meta-Analysis.Cancers · 2022Article
- A Noninvasive Risk Stratification Tool Build Using an Artificial Intelligence Approach for Colorectal Polyps Based on Annual Checkup Data.Healthcare (Basel, Switzerland) · 2022Article
- Relationship between maximum occlusal force and gastrointestinal cancer in community-dwelling older Japanese adults.Scientific reports · 2022Article
- Two-Sample Mendelian Randomization Analysis of Associations Between Periodontal Disease and Risk of Cancer.JNCI cancer spectrum · 2021Article
- The Association between Periodontitis and Human Colorectal Cancer: Genetic and Pathogenic Linkage.Life (Basel, Switzerland) · 2020Article
- Periodontal Disease, Tooth Loss, and Risk of Serrated Polyps and Conventional Adenomas.Cancer prevention research (Philadelphia, Pa.) · 2020Observational
- Periodontal disease and cancer: Epidemiologic studies and possible mechanisms.Periodontology 2000 · 2020Review
- The Oral Microbiome and Cancer.Frontiers in immunology · 2020Review
- Self-reported and clinical periodontal conditions in a group of Eastern European postpartum women.PloS one · 2020Article
- The association between self-reported poor oral health and gastrointestinal cancer risk in the UK Biobank: A large prospective cohort study.United European gastroenterology journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundWhile studies have shown that poor oral health status may increase the risk of cancer, evidence of a specific association with the risk of colorectal cancer (CRC) is inconclusive. We evaluated the association between oral health and CRC risk using data from three large cohorts: the Shanghai Men's Health Study (SMHS), the Shanghai Women's Health Study (SWHS), and the Southern Community Cohort Study (SCCS), and carried out a meta-analysis of results from other relevant published studies. PATIENTS AND
methodsThis study applied a nested case-control study design and included 825 cases/3298 controls from the SMHS/SWHS and 238 cases/2258 controls from the SCCS. The association between oral health status (i.e. tooth loss/tooth decay) and CRC risk was assessed using conditional logistic regression models. A meta-analysis was carried out based on results from the present study and three published studies.
resultsWe found that tooth loss was not associated with increased risk of CRC. ORs and respective 95% CIs associated with loss of 1-5, 6-10, and >10 teeth compared with those with full teeth are 0.87 (0.69-1.10), 0.93 (0.70-1.24), and 0.85 (0.66-1.11) among SMHS/SWHS participants; and 1.13 (0.72-1.79), 0.87 (0.52-1.43), and 1.00 (0.63-1.58) for those with loss of 1-4, 5-10, and >10 teeth among SCCS participants. Data regarding tooth decay were available in the SCCS, but were not associated with CRC risk. Meta-analysis confirmed the null association between tooth loss/periodontal disease and CRC risk (OR 1.05, 95% CI 0.86-1.29).
conclusionIn this analysis of three cohorts and a meta-analysis, we found no evidence supporting an association between oral health and CRC risk.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.