Evidence map›Paper›PMID 27217502›Full record

ArticleStroke2016

Picturing the Size and Site of Stroke With an Expanded National Institutes of Health Stroke Scale.

Daniel Agis, Maria B Goggins, Kumiko Oishi, Kenichi Oishi, Cameron Davis, Amy Wright, Eun Hye Kim, Rajani Sebastian, Donna C Tippett, Andreia Faria and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 56 citations in OpenAlex.

  1. Trial
  2. White Matter Hyperintensities as a Predictor of Aphasia Recovery.Archives of physical medicine and rehabilitation · 2024
    Trial
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  16. Clinical Guidelines for Eliciting Discourse Using the RHDBank Protocol.American journal of speech-language pathology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Daniel AgisFrom the Deparment of Neurology, Johns Hopkins University, Baltimore, MD (D.A., A.E.H.); School of Medicine, University College Dublin, Dublin, Ireland (M.B.G.); and Departments of Radiology (Kumiko Oishi, Kenichi Oishi, A.F.), Neurology (C.D., A.W., E.H.K., R.S., D.C.T., A.E.H.), Otolaryngology (D.C.T.), and PM&R (D.C.T., A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD.
Maria B GogginsFrom the Deparment of Neurology, Johns Hopkins University, Baltimore, MD (D.A., A.E.H.); School of Medicine, University College Dublin, Dublin, Ireland (M.B.G.); and Departments of Radiology (Kumiko Oishi, Kenichi Oishi, A.F.), Neurology (C.D., A.W., E.H.K., R.S., D.C.T., A.E.H.), Otolaryngology (D.C.T.), and PM&R (D.C.T., A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD.
Kumiko OishiFrom the Deparment of Neurology, Johns Hopkins University, Baltimore, MD (D.A., A.E.H.); School of Medicine, University College Dublin, Dublin, Ireland (M.B.G.); and Departments of Radiology (Kumiko Oishi, Kenichi Oishi, A.F.), Neurology (C.D., A.W., E.H.K., R.S., D.C.T., A.E.H.), Otolaryngology (D.C.T.), and PM&R (D.C.T., A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD.
Kenichi OishiFrom the Deparment of Neurology, Johns Hopkins University, Baltimore, MD (D.A., A.E.H.); School of Medicine, University College Dublin, Dublin, Ireland (M.B.G.); and Departments of Radiology (Kumiko Oishi, Kenichi Oishi, A.F.), Neurology (C.D., A.W., E.H.K., R.S., D.C.T., A.E.H.), Otolaryngology (D.C.T.), and PM&R (D.C.T., A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD.
Cameron DavisFrom the Deparment of Neurology, Johns Hopkins University, Baltimore, MD (D.A., A.E.H.); School of Medicine, University College Dublin, Dublin, Ireland (M.B.G.); and Departments of Radiology (Kumiko Oishi, Kenichi Oishi, A.F.), Neurology (C.D., A.W., E.H.K., R.S., D.C.T., A.E.H.), Otolaryngology (D.C.T.), and PM&R (D.C.T., A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD.
Amy WrightFrom the Deparment of Neurology, Johns Hopkins University, Baltimore, MD (D.A., A.E.H.); School of Medicine, University College Dublin, Dublin, Ireland (M.B.G.); and Departments of Radiology (Kumiko Oishi, Kenichi Oishi, A.F.), Neurology (C.D., A.W., E.H.K., R.S., D.C.T., A.E.H.), Otolaryngology (D.C.T.), and PM&R (D.C.T., A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD.
Eun Hye KimFrom the Deparment of Neurology, Johns Hopkins University, Baltimore, MD (D.A., A.E.H.); School of Medicine, University College Dublin, Dublin, Ireland (M.B.G.); and Departments of Radiology (Kumiko Oishi, Kenichi Oishi, A.F.), Neurology (C.D., A.W., E.H.K., R.S., D.C.T., A.E.H.), Otolaryngology (D.C.T.), and PM&R (D.C.T., A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD.
Rajani SebastianFrom the Deparment of Neurology, Johns Hopkins University, Baltimore, MD (D.A., A.E.H.); School of Medicine, University College Dublin, Dublin, Ireland (M.B.G.); and Departments of Radiology (Kumiko Oishi, Kenichi Oishi, A.F.), Neurology (C.D., A.W., E.H.K., R.S., D.C.T., A.E.H.), Otolaryngology (D.C.T.), and PM&R (D.C.T., A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD.
Donna C TippettFrom the Deparment of Neurology, Johns Hopkins University, Baltimore, MD (D.A., A.E.H.); School of Medicine, University College Dublin, Dublin, Ireland (M.B.G.); and Departments of Radiology (Kumiko Oishi, Kenichi Oishi, A.F.), Neurology (C.D., A.W., E.H.K., R.S., D.C.T., A.E.H.), Otolaryngology (D.C.T.), and PM&R (D.C.T., A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD.
Andreia FariaFrom the Deparment of Neurology, Johns Hopkins University, Baltimore, MD (D.A., A.E.H.); School of Medicine, University College Dublin, Dublin, Ireland (M.B.G.); and Departments of Radiology (Kumiko Oishi, Kenichi Oishi, A.F.), Neurology (C.D., A.W., E.H.K., R.S., D.C.T., A.E.H.), Otolaryngology (D.C.T.), and PM&R (D.C.T., A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD.
Argye E HillisFrom the Deparment of Neurology, Johns Hopkins University, Baltimore, MD (D.A., A.E.H.); School of Medicine, University College Dublin, Dublin, Ireland (M.B.G.); and Departments of Radiology (Kumiko Oishi, Kenichi Oishi, A.F.), Neurology (C.D., A.W., E.H.K., R.S., D.C.T., A.E.H.), Otolaryngology (D.C.T.), and PM&R (D.C.T., A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD. argye@jhmi.edu.
Johns Hopkins University · USUniversity College Dublin · IE

Funding

YALE CENTER FOR THE: LEARNING &ATTENTIONP41RR013642 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARER, ELAINE L · 1998 to 2011
$21.9M
TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
Neural Basis of Lexical Deficits in Hyperacute StrokeR01DC005375 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Argye E. Hillis · 2002 to 2026
$11.8M
Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2016 to 2020
$5.9M
Neural Basis of Unilateral Spatial NeglectR01NS047691 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HILLIS, ARGYE E. · 2004 to 2013
$3.2M
NCRR NIH HHS P41 RR013642NIBIB NIH HHS P41 EB015909NICHD NIH HHS U54 HD090257NIDCD NIH HHS R01 DC005375NINDS NIH HHS R01 NS047691
6 · The paper itself

Abstract

background and purposeThe National Institutes of Health Stroke Scale (NIHSS) includes minimal assessment of cognitive function, particularly in right hemisphere (RH) stroke. Descriptions of the Cookie Theft picture from the NIHSS allow analyses that (1) correlate with aphasia severity and (2) identify communication deficits in RH stroke. We hypothesized that analysis of the picture description contributes valuable information about volume and location of acute stroke.

methodsWe evaluated 67 patients with acute ischemic stroke (34 left hemisphere [LH]; 33 RH) with the NIHSS, analysis of the Cookie Theft picture, and magnetic resonance imaging, compared with 35 sex- and age-matched controls. We evaluated descriptions for total content units (CU), syllables, ratio of left:right CU, CU/minute, and percent interpretive CU, based on previous studies. Lesion volume and percent damage to regions of interest were measured on diffusion-weighted imaging. Multivariable linear regression identified variables associated with infarct volume, independently of NIHSS score, age and sex.

resultsPatients with RH and LH stroke differed from controls, but not from each other, on CU, syllables/CU, and CU/minute. Left:right CU was lower in RH compared with LH stroke. CU, syllables/CU, and NIHSS each correlated with lesion volume in LH and RH stroke. Lesion volume was best accounted by a model that included CU, syllables/CU, NIHSS, left:right CU, percent interpretive CU, and age, in LH and RH stroke. Each discourse variable and NIHSS score were associated with percent damage to different regions of interest, independently of lesion volume and age.

conclusionsBrief picture description analysis complements NIHSS scores in predicting stroke volume and location.

Indexed as

AgedAged, 80 and overAphasiaCerebral ArteriesCognition DisordersCommunication DisordersDiffusion Magnetic Resonance ImagingFemaleFunctional LateralityHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNational Institutes of Health (U.S.)Neuropsychological Testsaphasiacognition disorderslinear modelsmagnetic resonance imagingstroke

Identifiers

PMID27217502
PMCPMC4878287
OpenAlexW2345446444

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.