ArticlePlant physiology2016
The Pseudomonas syringae Type III Effector HopG1 Induces Actin Remodeling to Promote Symptom Development and Susceptibility during Infection.
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Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36citing papers in PubMed
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36 citing papers in PubMed, 70 citations in OpenAlex.
- Symbiont effectors modulate plant signaling to increase host stress resilience.Plant physiology · 2026Article
- BUI1 coordinates actin cytoskeleton remodeling and ROS homeostasis to confer broad-spectrum disease resistance in rice.Stress biology · 2026Article
- VopX, a novelmBio · 2025Article
- A Ralstonia solanacearum type III effector alters the actin and microtubule cytoskeleton to promote bacterial virulence in plants.PLoS pathogens · 2024Article
- Arabidopsis Actin-Binding Protein WLIM2A Links PAMP-Triggered Immunity and Cytoskeleton Organization.International journal of molecular sciences · 2024Article
- Logistics of defense: The contribution of endomembranes to plant innate immunity.The Journal of cell biology · 2024Review
- Heat-induced SUMOylation differentially affects bacterial effectors in plant cells.The Plant cell · 2024Article
- NET4 and RabG3 link actin to the tonoplast and facilitate cytoskeletal remodelling during stomatal immunity.Nature communications · 2023Article
- ILEE: Algorithms and toolbox for unguided and accurate quantitative analysis of cytoskeletal images.The Journal of cell biology · 2023Article
- TheFrontiers in microbiology · 2023Article
- The Cytoskeleton in Plant Immunity: Dynamics, Regulation, and Function.International journal of molecular sciences · 2022Review
- Metaeffector interactions modulate the type III effector-triggered immunity load of Pseudomonas syringae.PLoS pathogens · 2022Article
- The Pseudomonas syringae type III effector HopG1 triggers necrotic cell death that is attenuated by AtNHR2B.Scientific reports · 2022Article
- Molecular and Genomic Characterization of theMicroorganisms · 2022Article
- Plant susceptible responses: the underestimated side of plant-pathogen interactions.Biological reviews of the Cambridge Philosophical Society · 2022Review
- In planta transcriptomics reveals conflicts between pattern-triggered immunity and the AlgU sigma factor regulon.PloS one · 2022Article
- Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation.Nature communications · 2021Article
- What the Wild Things Do: Mechanisms of Plant Host Manipulation by Bacterial Type III-Secreted Effector Proteins.Microorganisms · 2021Review
- In-silico structural analysis of Pseudomonas syringae effector HopZ3 reveals ligand binding activity and virulence function.Journal of plant research · 2021Article
- Lineage-Specific Rewiring of Core Pathways Predating Innovation of Legume Nodules Shapes Symbiotic Efficiency.mSystems · 2021Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Masaki ShimonoDepartment of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, Michigan 48824 (M.S., Y.-J.L., B.D.); Graduate Program in Cell and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 (K.P., S.Y.H., B.D.); Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824 (B.H.K., S.Y.H.); Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-2064 (J.H.-R., C.J.S.); Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation, Michigan State University, East Lansing, Michigan 48824 (S.Y.H.); Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon 97331-7303 (J.H.C.);Bindley Bioscience Center, Discovery Park, Purdue University, West Lafayette, Indiana 47907 (C.J.S.); and Graduate Program in Genetics, Michigan State University, East Lansing, Michigan 48824 (B.D.).
Yi-Ju LuDepartment of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, Michigan 48824 (M.S., Y.-J.L., B.D.); Graduate Program in Cell and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 (K.P., S.Y.H., B.D.); Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824 (B.H.K., S.Y.H.); Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-2064 (J.H.-R., C.J.S.); Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation, Michigan State University, East Lansing, Michigan 48824 (S.Y.H.); Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon 97331-7303 (J.H.C.);Bindley Bioscience Center, Discovery Park, Purdue University, West Lafayette, Indiana 47907 (C.J.S.); and Graduate Program in Genetics, Michigan State University, East Lansing, Michigan 48824 (B.D.).ORCID 0000-0002-9590-8315
Katie PorterDepartment of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, Michigan 48824 (M.S., Y.-J.L., B.D.); Graduate Program in Cell and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 (K.P., S.Y.H., B.D.); Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824 (B.H.K., S.Y.H.); Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-2064 (J.H.-R., C.J.S.); Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation, Michigan State University, East Lansing, Michigan 48824 (S.Y.H.); Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon 97331-7303 (J.H.C.);Bindley Bioscience Center, Discovery Park, Purdue University, West Lafayette, Indiana 47907 (C.J.S.); and Graduate Program in Genetics, Michigan State University, East Lansing, Michigan 48824 (B.D.).
Brian H KvitkoDepartment of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, Michigan 48824 (M.S., Y.-J.L., B.D.); Graduate Program in Cell and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 (K.P., S.Y.H., B.D.); Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824 (B.H.K., S.Y.H.); Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-2064 (J.H.-R., C.J.S.); Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation, Michigan State University, East Lansing, Michigan 48824 (S.Y.H.); Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon 97331-7303 (J.H.C.);Bindley Bioscience Center, Discovery Park, Purdue University, West Lafayette, Indiana 47907 (C.J.S.); and Graduate Program in Genetics, Michigan State University, East Lansing, Michigan 48824 (B.D.).
Jessica Henty-RidillaDepartment of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, Michigan 48824 (M.S., Y.-J.L., B.D.); Graduate Program in Cell and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 (K.P., S.Y.H., B.D.); Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824 (B.H.K., S.Y.H.); Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-2064 (J.H.-R., C.J.S.); Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation, Michigan State University, East Lansing, Michigan 48824 (S.Y.H.); Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon 97331-7303 (J.H.C.);Bindley Bioscience Center, Discovery Park, Purdue University, West Lafayette, Indiana 47907 (C.J.S.); and Graduate Program in Genetics, Michigan State University, East Lansing, Michigan 48824 (B.D.).
Allison CreasonDepartment of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, Michigan 48824 (M.S., Y.-J.L., B.D.); Graduate Program in Cell and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 (K.P., S.Y.H., B.D.); Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824 (B.H.K., S.Y.H.); Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-2064 (J.H.-R., C.J.S.); Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation, Michigan State University, East Lansing, Michigan 48824 (S.Y.H.); Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon 97331-7303 (J.H.C.);Bindley Bioscience Center, Discovery Park, Purdue University, West Lafayette, Indiana 47907 (C.J.S.); and Graduate Program in Genetics, Michigan State University, East Lansing, Michigan 48824 (B.D.).
Sheng Yang HeDepartment of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, Michigan 48824 (M.S., Y.-J.L., B.D.); Graduate Program in Cell and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 (K.P., S.Y.H., B.D.); Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824 (B.H.K., S.Y.H.); Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-2064 (J.H.-R., C.J.S.); Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation, Michigan State University, East Lansing, Michigan 48824 (S.Y.H.); Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon 97331-7303 (J.H.C.);Bindley Bioscience Center, Discovery Park, Purdue University, West Lafayette, Indiana 47907 (C.J.S.); and Graduate Program in Genetics, Michigan State University, East Lansing, Michigan 48824 (B.D.).ORCID 0000-0003-1308-498X
Jeff H ChangDepartment of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, Michigan 48824 (M.S., Y.-J.L., B.D.); Graduate Program in Cell and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 (K.P., S.Y.H., B.D.); Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824 (B.H.K., S.Y.H.); Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-2064 (J.H.-R., C.J.S.); Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation, Michigan State University, East Lansing, Michigan 48824 (S.Y.H.); Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon 97331-7303 (J.H.C.);Bindley Bioscience Center, Discovery Park, Purdue University, West Lafayette, Indiana 47907 (C.J.S.); and Graduate Program in Genetics, Michigan State University, East Lansing, Michigan 48824 (B.D.).
Christopher J StaigerDepartment of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, Michigan 48824 (M.S., Y.-J.L., B.D.); Graduate Program in Cell and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 (K.P., S.Y.H., B.D.); Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824 (B.H.K., S.Y.H.); Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-2064 (J.H.-R., C.J.S.); Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation, Michigan State University, East Lansing, Michigan 48824 (S.Y.H.); Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon 97331-7303 (J.H.C.);Bindley Bioscience Center, Discovery Park, Purdue University, West Lafayette, Indiana 47907 (C.J.S.); and Graduate Program in Genetics, Michigan State University, East Lansing, Michigan 48824 (B.D.).
Brad DayDepartment of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, Michigan 48824 (M.S., Y.-J.L., B.D.); Graduate Program in Cell and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 (K.P., S.Y.H., B.D.); Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824 (B.H.K., S.Y.H.); Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-2064 (J.H.-R., C.J.S.); Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331-7303 (A.C., J.H.C.);Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation, Michigan State University, East Lansing, Michigan 48824 (S.Y.H.); Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon 97331-7303 (J.H.C.);Bindley Bioscience Center, Discovery Park, Purdue University, West Lafayette, Indiana 47907 (C.J.S.); and Graduate Program in Genetics, Michigan State University, East Lansing, Michigan 48824 (B.D.) bday@msu.edu.ORCID 0000-0002-9880-4319
Michigan State University · USOregon State University · USPurdue University West Lafayette · USHoward Hughes Medical Institute · US
Funding
Howard Hughes Medical Institute
Abstract
The plant cytoskeleton underpins the function of a multitude of cellular mechanisms, including those associated with developmental- and stress-associated signaling processes. In recent years, the actin cytoskeleton has been demonstrated to play a key role in plant immune signaling, including a recent demonstration that pathogens target actin filaments to block plant defense and immunity. Herein, we quantified spatial changes in host actin filament organization after infection with Pseudomonas syringae pv. tomato DC3000 (Pst DC3000), demonstrating that the type-III effector HopG1 is required for pathogen-induced changes to actin filament architecture and host disease symptom development during infection. Using a suite of pathogen effector deletion constructs, coupled with high-resolution microscopy, we found that deletion of hopG1 from Pst DC3000 resulted in a reduction in actin bundling and a concomitant increase in the density of filament arrays in Arabidopsis, both of which correlate with host disease symptom development. As a mechanism underpinning this activity, we further show that the HopG1 effector interacts with an Arabidopsis mitochondrial-localized kinesin motor protein. Kinesin mutant plants show reduced disease symptoms after pathogen infection, which can be complemented by actin-modifying agents. In total, our results support a model in which HopG1 induces changes in the organization of the actin cytoskeleton as part of its virulence function in promoting disease symptom development.
Indexed as
ActinsArabidopsisBacterial ProteinsCytoskeletonGenetic Complementation TestHost-Pathogen InteractionsKinesinsMutationNicotianaPlant DiseasesPseudomonas syringaeActinsBacterial ProteinsKinesins
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