Evidence map›Paper›PMID 27217442›Full record

ArticleAntimicrobial agents and chemotherapy2016

An Immunocompromised Child with Bloodstream Infection Caused by Two Escherichia coli Strains, One Harboring NDM-5 and the Other Harboring OXA-48-Like Carbapenemase.

M Earth Hasassri, Thomas G Boyce, Andrew P Norgan, Scott A Cunningham, Patricio R Jeraldo, Scott J Weissman, Robin Patel, Ritu Banerjee, Jason M Pogue, Keith S Kaye

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Genomic Characterization of a Multidrug-ResistantInfection and drug resistance · 2022
    Article
  4. Article
  5. OXA-48-like carbapenemases producing Enterobacteriaceae in different niches.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018
    Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

M Earth HasassriMayo Clinic College of Medicine, Rochester, Minnesota, USA.ORCID 0000-0003-1797-1826
Thomas G BoyceDivision of Pediatric Infectious Diseases, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Andrew P NorganDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Scott A CunninghamDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Patricio R JeraldoDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-0282-4217
Scott J WeissmanSeattle Children's Research Institute, Seattle, Washington, USA.
Robin PatelDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Ritu BanerjeeDivision of Pediatric Infectious Diseases, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA banerjee.ritu@mayo.edu Kkaye@dmc.org.
Jason M PogueWayne State University and Detroit Medical Center, Detroit, Michigan, USA.
Keith S KayeWayne State University and Detroit Medical Center, Detroit, Michigan, USA banerjee.ritu@mayo.edu Kkaye@dmc.org.
Mayo Clinic · USMayo Clinic in Florida · USWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe a 16-year-old neutropenic patient from the Middle East with bloodstream infection caused by two carbapenemase-producing Escherichia coli isolates that we characterized by whole-genome sequencing. While one displayed meropenem resistance and was blaNDM positive, the other demonstrated meropenem susceptibility yet harbored blaOXA181 (which encodes a blaOXA48-like enzyme). This report highlights the challenge of laboratory detection of blaOXA48-like enzymes and the clinical implications of genotypic resistance detection in carbapenemase-producing Enterobacteriaceae.

Indexed as

AdolescentAmikacinAnti-Bacterial AgentsAztreonamBacterial Proteinsbeta-Lactamasesbeta-LactamsCiprofloxacinErtapenemEscherichia coliFemaleGentamicinsHumansImmunocompromised HostMeropenemPenicillanic AcidAmikacinAnti-Bacterial AgentsAztreonamBacterial Proteinsbeta-Lactamasesbeta-LactamscarbapenemaseCiprofloxacinErtapenemGentamicinsMeropenemPenicillanic AcidPiperacillinPiperacillin, Tazobactam Drug CombinationTazobactamThienamycinsTobramycin

Identifiers

PMID27217442
PMCPMC4879384
OpenAlexW2395388118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.