Evidence map›Paper›PMID 27217298›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2016

Impact of Human Mutant TGFβ1/Fc Protein on Memory and Regulatory T Cell Homeostasis Following Lymphodepletion in Nonhuman Primates.

H Guo, L Lu, R Wang, A Perez-Gutierrez, H S Abdulkerim, A F Zahorchak, T L Sumpter, K A Reimann, A W Thomson, M B Ezzelarab

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

H GuoDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
L LuDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
R WangMassBiologics, University of Massachusetts Medical School, Boston, MA.
A Perez-GutierrezDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
H S AbdulkerimMassBiologics, University of Massachusetts Medical School, Boston, MA.
A F ZahorchakDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
T L SumpterDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
K A ReimannMassBiologics, University of Massachusetts Medical School, Boston, MA.
A W ThomsonDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
M B EzzelarabDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
University of Pittsburgh · USUniversity of Massachusetts Chan Medical School · US

Funding

Nonhuman Primate Reagent ResourceU24AI126683 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2016 to 2026
$20.1M
Tomotherapy and Hematopoietic Stem Cells For Tolerance to Kidney TransplantsU01AI102456 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KAUFMAN, DIXON B · 2012 to 2022
$19.2M
Resource for Nonhuman Primate Cell Depleting AntibodiesR24OD010976 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ENGELMAN, KATHLEEN, MAGNANI, DIOGO · 2012 to 2019
$4.7M
Alemtuzumab and Regulatory T Cells for Heart Transplant Tolerance in MonkeysU01AI091197 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THOMSON, ANGUS W · 2010 to 2016
$4.3M
Clinical Islet Transplantation at NorthwesternU01AI089316 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUO, XUNRONG · 2009 to 2011
$3.4M
Manipulating Neuropeptide Receptors in Mast Cells for Atopic Dermatitis TreatmentK01AR067250 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SUMPTER, TINA L · 2015 to 2019
$437k
NIAID NIH HHS HHSN272201300031CNIAID NIH HHS U01 AI089316NIAID NIH HHS U01 AI091197NIAID NIH HHS U01 AI102456NIAID NIH HHS U24 AI126683NIAMS NIH HHS K01 AR067250NIH HHS R24 OD010976
6 · The paper itself

Abstract

Transforming growth factor β1 (TGFβ1) plays a key role in T cell homeostasis and peripheral tolerance. We evaluated the influence of a novel human mutant TGFβ1/Fc (human IgG4 Fc) fusion protein on memory CD4

Indexed as

AnimalsHomeostasisHumansImmunologic MemoryLeukocytes, MononuclearLymphocyte DepletionMacaca mulattaMaleReceptors, FcT-Lymphocytes, RegulatoryTransforming Growth Factor beta1Receptors, FcTransforming Growth Factor beta1animal models: nonhuman primatebasic (laboratory) research/sciencefusion proteins and monoclonal antibodiesimmune regulationimmunobiologyimmunosuppressantimmunosuppression/immune modulationT cell biologytolerance

Identifiers

PMID27217298
PMCPMC5121100
OpenAlexW2396476476

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.