SynthesisClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016
Metaanalysis of the Performance of a Combined Treponemal and Nontreponemal Rapid Diagnostic Test for Syphilis and Yaws.
Synthesis in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Improved rapid diagnostic tests to detect syphilis and yaws: a systematic review and meta-analysis.Sexually transmitted infections · 2022Pooled it
- The impact of antenatal syphilis point of care testing on pregnancy outcomes: A systematic review.PloS one · 2021Pooled it
- Diagnosing sexually transmitted infections in resource-constrained settings: challenges and ways forward.Journal of the International AIDS Society · 2019Pooled it
- Evaluating the MedMira Multiplo® Complete Syphilis (TP/nTP) antibody test in a sexually transmitted infection clinic in Ottawa, Canada: increased rapid diagnosis and improved antibiotic stewardship.BMC infectious diseases · 2025Trial
- Prevalence of five treatable sexually transmitted infections among women in Lower River region of The Gambia.BMC infectious diseases · 2023Trial
- Trial of Three Rounds of Mass Azithromycin Administration for Yaws Eradication.The New England journal of medicine · 2022Trial
- Antibody Responses to Two Recombinant Treponemal Antigens (rp17 and TmpA) before and after Azithromycin Treatment for Yaws in Ghana and Papua New Guinea.Journal of clinical microbiology · 2021Trial
- Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea.The Lancet. Global health · 2018Trial
- Rapid/point-of-care syphilis testing in high-income countries: insights and implementation challenges from the authors' experience in Canada.Journal of clinical microbiology · 2026Review
- The Potential for Combined Treponemal/Nontreponemal Rapid Point-of-Care Test and Treponema pallidum Polymerase Chain Reaction in the Diagnosis of Gestational and Congenital Syphilis in a Low-Resource, High-Prevalence Setting: Pilot Data From Malawi.Sexually transmitted diseases · 2026Article
- Assessment of the role of Haemophilus ducreyi coinfection on outcomes of Yaws treatment in the southwestern part of Ghana.PLoS neglected tropical diseases · 2026Article
- Field evaluation of a dual treponemal/non-treponemal point-of-care test for syphilis within an HIV pre-exposure prophylaxis programme in Hanoi, Vietnam.Sexually transmitted infections · 2025Article
- Clinical development and performance of the First to Know Syphilis Self-Test for over-the-counter usage: aJournal of clinical microbiology · 2025Article
- Guidance for conducting and evaluating serological surveys to assess interruption of yaws transmission in the context of an eradication target.PLoS neglected tropical diseases · 2025Article
- Update on syphilis diagnostics.Current opinion in infectious diseases · 2025Review
- Rapid Serologic Test for Diagnosis of Yaws in Patients with Suspicious Skin Ulcers.Emerging infectious diseases · 2023Article
- Point-of-Care Diagnostics for Diagnosis of Active Syphilis Infection: Needs, Challenges and the Way Forward.International journal of environmental research and public health · 2022Article
- Laboratory Evaluation of the DPP Syphilis Screen & Confirm Assay.Microbiology spectrum · 2022Article
- Limited syphilis testing for key populations in Zimbabwe: A silent public health threat.Southern African journal of infectious diseases · 2022Article
- A New Call to Action to Combat an Old Nemesis: Addressing Rising Congenital Syphilis Rates in the United States.Journal of women's health (2002) · 2021Article
Corrections and comments
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Authors and funding
18 authors at 11 institutions in 10 countries.
Funding
Abstract
backgroundThe human treponematoses are important causes of disease. Mother-to-child transmission of syphilis remains a major cause of stillbirth and neonatal death. There are also almost 100 000 cases of endemic treponemal disease reported annually, predominantly yaws. Rapid diagnostic tests (RDTs) would improve access to screening for these diseases. Most RDTs cannot distinguish current and previous infection. The Dual Path Platform (DPP) Syphilis Screen & Confirm test includes both a treponemal (T1) and nontreponemal (T2) component and may improve the accuracy of diagnosis.
methodsWe conducted a metaanalysis of published and unpublished evaluations of the DPP-RDT for the diagnosis of syphilis and yaws. We calculated the sensitivity, specificity, and overall agreement of the test compared with reference laboratory tests.
resultsNine evaluations, including 7267 tests, were included. Sensitivity was higher in patients with higher titer rapid plasma reagin (≥1:16) for both the T1 (98.2% vs 90.1%, P < .0001) and the T2 component (98.2% vs 80.6%, P < .0001). Overall agreement between the DPP test and reference serology was 85.2% (84.4%-86.1%). Agreement was highest for high-titer active infection and lowest for past infection.
conclusionsThe RDT has good sensitivity and specificity of the treponemal and nontreponemal components both in cases of suspected syphilis and yaws, although the sensitivity is decreased at lower antibody titers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.