Evidence map›Paper›PMID 27217153›Full record

ArticleMolecular psychiatry2017

Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study.

E Walton, J-B Pingault, C A M Cecil, T R Gaunt, C L Relton, J Mill, E D Barker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 9 pooled it
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 9 syntheses or guidelines pooled it, 166 citations in OpenAlex.

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  9. The Association between Lead and Attention-Deficit/Hyperactivity Disorder: A Systematic Review.International journal of environmental research and public health · 2019
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

E WaltonDepartment of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
J-B PingaultDivision of Psychology and Language Sciences, University College London, London, UK.
C A M CecilDepartment of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
T R GauntMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
C L ReltonMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
J MillMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
E D BarkerDepartment of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
King's College London · GBMedical Research Council · GBUniversity College London · GB

Funding

Epigenetic Pathways to Conduct Problem Trajectories: Early Environmental RisksR01HD068437 · NICHD · KING'S COLLEGE LONDON · PI BARKER, EDWARD D., MILL, JONATHAN · 2012 to 2014
$1.1M
Biotechnology and Biological Sciences Research Council BB/I025263/1Biotechnology and Biological Sciences Research Council BBI025751/1Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_UU_12013/2Medical Research Council MC_UU_12013/8NICHD NIH HHS R01 HD068437Wellcome Trust 092731Wellcome Trust 102215
6 · The paper itself

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent developmental disorder, associated with a range of long-term impairments. Variation in DNA methylation, an epigenetic mechanism, is implicated in both neurobiological functioning and psychiatric health. However, the potential role of DNA methylation in ADHD symptoms is currently unclear. In this study, we examined data from the Avon Longitudinal Study of Parents and Children (ALSPAC)-specifically the subsample forming the Accessible Resource for Integrated Epigenomics Studies (ARIES)-that includes (1) peripheral measures of DNA methylation (Illumina 450k) at birth (n=817, 49% male) and age 7 (n=892, 50% male) and (2) trajectories of ADHD symptoms (7-15 years). We first employed a genome-wide analysis to test whether DNA methylation at birth associates with later ADHD trajectories; and then followed up at age 7 to investigate the stability of associations across early childhood. We found that DNA methylation at birth differentiated ADHD trajectories across multiple genomic locations, including probes annotated to SKI (involved in neural tube development), ZNF544 (previously implicated in ADHD), ST3GAL3 (linked to intellectual disability) and PEX2 (related to perixosomal processes). None of these probes maintained an association with ADHD trajectories at age 7. Findings lend novel insights into the epigenetic landscape of ADHD symptoms, highlighting the potential importance of DNA methylation variation in genes related to neurodevelopmental and peroxisomal processes that play a key role in the maturation and stability of cortical circuits.

Indexed as

AdolescentAttention Deficit Disorder with HyperactivityChildDNA FingerprintingDNA MethylationEpigenesis, GeneticEpigenomicsFemaleHumansInfant, NewbornLongitudinal StudiesMaleProspective Studies

Identifiers

PMID27217153
PMCPMC5014094
OpenAlexW2342457463

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.