ArticleSocial cognitive and affective neuroscience2016
Disentangling the roles of arousal and amygdala activation in emotional declarative memory.
Article in Social cognitive and affective neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Divergent modes of episodic organization underlie whether emotional learning enhances memory across event boundaries.Psychonomic bulletin & review · 2026Article
- Article
- Look Fear in the Eyes: The Influence of Emotion Regulation on Spider Size Estimation-A Pupillometry Study.Psychophysiology · 2025Article
- Distortion of overlapping memories relates to arousal and anxiety.Cognitive, affective & behavioral neuroscience · 2025Article
- Semantic structures facilitate threat memory integration throughout the medial temporal lobe and medial prefrontal cortex.Current biology : CB · 2024Article
- Increasing the complexity of isolated musical chords benefits concurrent associative memory formation.Scientific reports · 2023Article
- Neuronal activity in the human amygdala and hippocampus enhances emotional memory encoding.Nature human behaviour · 2023Article
- Not all bad decisions are alike: approach and avoidant bad decisions are associated with distinct network organization.Frontiers in neuroscience · 2023Article
- Laboratory models of post-traumatic stress disorder: The elusive bridge to translation.Neuron · 2022Review
- Article
- Aversive learning strengthens episodic memory in both adolescents and adults.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Episodic memory and Pavlovian conditioning: ships passing in the night.Current opinion in behavioral sciences · 2019Article
- A reminder before extinction strengthens episodic memory via reconsolidation but fails to disrupt generalized threat responses.Scientific reports · 2017Article
- The Neuroanatomical, Neurophysiological and Psychological Basis of Memory: Current Models and Their Origins.Frontiers in pharmacology · 2017Review
- Review
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
A large body of evidence in animals and humans implicates the amygdala in promoting memory for arousing experiences. Although the amygdala can trigger threat-related noradrenergic-sympathetic arousal, in humans amygdala activation and noradrenergic-sympathetic arousal do not always concur. This raises the question how these two processes play a role in enhancing emotional declarative memory. This study was designed to disentangle these processes in a combined subsequent-memory/fear-conditioning paradigm with neutral items belonging to two conceptual categories as conditioned stimuli. Functional MRI, skin conductance (index of sympathetic activity), and pupil dilation (indirect index of central noradrenergic activity) were acquired throughout procedures. Recognition memory for individual items was tested 24 h later. We found that pupil dilation and skin conductance responses were higher on CS+ (associated with a shock) compared with CS- trials, irrespective of later memory for those items. By contrast, amygdala activity was only higher for CS+ items that were later confidently remembered compared with CS+ items that were later forgotten. Thus, amygdala activity and not noradrenergic-sympathetic arousal, predicted enhanced declarative item memory. This dissociation is in line with animal models stating that the amygdala integrates arousal-related neuromodulatory changes to alter mnemonic processes elsewhere in the brain.
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