ArticleDevelopment genes and evolution2016
Craniofacial shape transition across the house mouse hybrid zone: implications for the genetic architecture and evolution of between-species differences.
Article in Development genes and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Independent evolution toward larger body size in the distinctive Faroe Island mice.G3 (Bethesda, Md.) · 2021Pooled it
- Body size and cranial shape differentiation in urban and rural house mice (bioRxiv : the preprint server for biology · 2026Article
- Beyond Mendel: a call to revisit the genotype-phenotype map through new experimental paradigms.Genetics · 2026Article
- Association of tameness and sociability but no sign of domestication syndrome in mice selectively bred for active tameness.Genes, brain, and behavior · 2024Article
- Craniodental divergence associated with bite force between hybridizing pine squirrels (Tamiasciurus).PloS one · 2023Article
- Testing the accuracy of 3D automatic landmarking via genome-wide association studies.G3 (Bethesda, Md.) · 2022Article
- Geometric morphometric investigation of craniofacial morphological change in domesticated silver foxes.Scientific reports · 2021Article
- Mouse Skull Mean Shape and Shape Robustness Rely on Different Genetic Architectures and Different Loci.Frontiers in genetics · 2019Article
- Bracketing phenogenotypic limits of mammalian hybridization.Royal Society open science · 2018Article
- Craniomandibular form and body size variation of first generation mouse hybrids: A model for hominin hybridization.Journal of human evolution · 2018Article
- Article
- Creating diversity in mammalian facial morphology: a review of potential developmental mechanisms.EvoDevo · 2018Review
- Genomic regions controlling shape variation in the first upper molar of the house mouse.eLife · 2017Article
- A population level atlas of Mus musculus craniofacial skeleton and automated image-based shape analysis.Journal of anatomy · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Craniofacial shape differences between taxa have often been linked to environmental adaptation, e.g., new food sources, or have been studied in the context of domestication. Evidence for the genetic basis of such phenotypic differences to date suggests that between-species as well as between-population variation has an oligogenic basis, i.e., few loci of large effect explain most of the variation. In mice, it has been shown that within-population craniofacial variation has a highly polygenic basis, but there are no data regarding the genetic basis of between-species differences in natural populations. Here, we address this question using a phenotype-focused approach. Using 3D geometric morphometrics, we phenotyped a panel of mice derived from a natural hybrid zone between Mus musculus domesticus and Mus mus musculus and quantify the transition of craniofacial shape along the hybridization gradient. We find a continuous shape transition along the hybridization gradient and unaltered developmental stability associated with hybridization. This suggests that the morphospace between the two subspecies is continuous despite reproductive isolation and strong barriers to gene flow. We show that quantitative changes in overall genome composition generate quantitative changes in craniofacial shape; this supports a highly polygenic basis for between-species craniofacial differences in the house mouse. We discuss our findings in the context of oligogenic versus polygenic models of the genetic architecture of morphological traits.
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