ArticleJournal of neural transmission (Vienna, Austria : 1996)2016
The primate pedunculopontine nucleus region: towards a dual role in locomotion and waking state.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Excessive daytime sleepiness in a model of Parkinson's disease improved by low-frequency stimulation of the pedunculopontine nucleus.NPJ Parkinson's disease · 2023Article
- Neurons innervating both the central amygdala and the ventral tegmental area encode different emotional valences.Frontiers in neuroscience · 2023Article
- The Arousal-motor Hypothesis of Dopamine Function: Evidence that Dopamine Facilitates Reward Seeking in Part by Maintaining Arousal.Neuroscience · 2022Article
- Gamma oscillations in the pedunculopontine nucleus are regulated by F-actin: neuroepigenetic implications.American journal of physiology. Cell physiology · 2020Article
- Neuroepigenetics of arousal: Gamma oscillations in the pedunculopontine nucleus.Journal of neuroscience research · 2019Review
- Bottom-up gamma maintenance in various disorders.Neurobiology of disease · 2019Review
- Proteomic measures of gamma oscillations.Heliyon · 2019Article
- Focus on the pedunculopontine nucleus. Consensus review from the May 2018 brainstem society meeting in Washington, DC, USA.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2019Review
- Local and Relayed Effects of Deep Brain Stimulation of the Pedunculopontine Nucleus.Brain sciences · 2019Review
- Bottom-up gamma and bipolar disorder, clinical and neuroepigenetic implications.Bipolar disorders · 2019Review
- Class II histone deacetylases require P/Q-type CaScientific reports · 2018Article
- Direct localisation of the human pedunculopontine nucleus using MRI: a coordinate and fibre-tracking study.European radiology · 2018Article
- A probabilistic template of human mesopontine tegmental nuclei from in vivo 7T MRI.NeuroImage · 2018Article
- Arousal and drug abuse.Behavioural brain research · 2017Review
- Bottom-up gamma and stages of waking.Medical hypotheses · 2017Article
- Dopamine and the Brainstem Locomotor Networks: From Lamprey to Human.Frontiers in neuroscience · 2017Review
- Speed and Oscillations: Medial Septum Integration of Attention and Navigation.Frontiers in systems neuroscience · 2017Review
- Role of calcium channels in bipolar disorder.Current psychopharmacology · 2017Article
- Bottom-up Gamma: the Pedunculopontine Nucleus and Reticular Activating System.Translational brain rhythmicity · 2016Article
- Arousal and the control of perception and movement.Current trends in neurology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mesencephalic reticular formation (MRF) mainly composed by the pedunculopontine and the cuneiform nuclei is involved in the control of several fundamental brain functions such as locomotion, rapid eye movement sleep and waking state. On the one hand, the role of MRF neurons in locomotion has been investigated for decades in different animal models, including in behaving nonhuman primate (NHP) using extracellular recordings. On the other hand, MRF neurons involved in the control of waking state have been consistently shown to constitute the cholinergic component of the reticular ascending system. However, a dual control of the locomotion and waking state by the same groups of neurons in NHP has never been demonstrated in NHP. Here, using microelectrode recordings in behaving NHP, we recorded 38 neurons in the MRF that were followed during transition between wakefulness (TWS) and sleep, i.e., until the emergence of sleep episodes characterized by typical cortical slow wave activity (SWA). We found that the MRF neurons, mainly located in the pedunculopontine nucleus region, modulated their activity during TWS with a decrease in firing rate during SWA. Of interest, we could follow some MRF neurons from locomotion to SWA and found that they also modulated their firing rate during locomotion and TWS. These new findings confirm the role of MRF neurons in both functions. They suggest that the MRF is an integration center that potentially allows to fine tune waking state and locomotor signals in order to establish an efficient locomotion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.