ArticleNucleic acids research2016
Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis.
Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Colon-Targeted astragalus polysaccharide nanoparticles prevent NAFLD-Driven hepatocarcinogenesis via microbiota remodeling and NF-κB Inhibition.Journal of experimental & clinical cancer research : CR · 2025Article
- Longitudinal big biological data in the AI era.Molecular systems biology · 2025Review
- Genome-scale models in human metabologenomics.Nature reviews. Genetics · 2025Review
- Weighted gene co-expression network analysis identified GBP2 connected to PPARα activity and liver cancer.Scientific reports · 2024Article
- Hepatitis B-related hepatocellular carcinoma: classification and prognostic model based on programmed cell death genes.Frontiers in immunology · 2024Article
- Signature of immune-related metabolic genes predicts the prognosis of hepatocellular carcinoma.Frontiers in immunology · 2024Article
- Role of follistatin-like protein 1 in liver diseases.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Polyphenols as potential metabolism mechanisms regulators in liver protection and liver cancer prevention.Cell proliferation · 2023Review
- Role of ferroptosis-related molecular patterns in hepatocellular carcinoma microenvironment.American journal of translational research · 2022Article
- Circ_0091581 Promotes the Progression of Hepatocellular Carcinoma Through Targeting miR-591/FOSL2 Axis.Digestive diseases and sciences · 2021Article
- Network of clinically-relevant lncRNAs-mRNAs associated with prognosis of hepatocellular carcinoma patients.Scientific reports · 2020Article
- Bioinformatics analysis of different candidate genes involved in hepatocellular carcinoma induced by HepG2 cells or tumor cells of patients.The Journal of international medical research · 2020Article
- Identification of a prognostic signature of nine metabolism-related genes for hepatocellular carcinoma.PeerJ · 2020Article
- Urinary Metabolites Diagnostic and Prognostic of Intrahepatic Cholangiocarcinoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Article
- A Logistic Regression Model for Noninvasive Prediction of AFP-Negative Hepatocellular Carcinoma.Technology in cancer research & treatment · 2019Article
- Effect of serum triglyceride level on the prognosis of patients with hepatocellular carcinoma in the absence of cirrhosis.Lipids in health and disease · 2018Article
- Immunometabolism: A novel perspective of liver cancer microenvironment and its influence on tumor progression.World journal of gastroenterology · 2018Review
- Systems biology in hepatology: approaches and applications.Nature reviews. Gastroenterology & hepatology · 2018Review
- Selenium Supplementation Alters Hepatic Energy and Fatty Acid Metabolism in Mice.The Journal of nutrition · 2018Article
- Dietary Supplement of Large Yellow Tea Ameliorates Metabolic Syndrome and Attenuates Hepatic Steatosis in db/db Mice.Nutrients · 2018Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) has a high mortality rate and early detection of HCC is crucial for the application of effective treatment strategies. HCC is typically caused by either viral hepatitis infection or by fatty liver disease. To diagnose and treat HCC it is necessary to elucidate the underlying molecular mechanisms. As a major cause for development of HCC is fatty liver disease, we here investigated anomalies in regulation of lipid metabolism in the liver. We applied a tailored network-based approach to identify signaling hubs associated with regulation of this part of metabolism. Using transcriptomics data of HCC patients, we identified significant dysregulated expressions of lipid-regulated genes, across many different lipid metabolic pathways. Our findings, however, show that viral hepatitis causes HCC by a distinct mechanism, less likely involving lipid anomalies. Based on our analysis we suggest signaling hub genes governing overall catabolic or anabolic pathways, as novel drug targets for treatment of HCC that involves lipid anomalies.
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