ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Heterogeneity of Human Aging and Its Assessment.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
105 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Influenza vaccine effectiveness according to frailty status in adults aged ≥ 50 years: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Pooled it
- BrainAGE, brain health, and mental disorders: A systematic review.Neuroscience and biobehavioral reviews · 2024Pooled it
- Systematic review of research barriers, facilitators, and stakeholders in long-term care and geriatric settings, and a conceptual mapping framework to build research capacity.BMC geriatrics · 2023Pooled it
- The SAFEST review: a mixed methods systematic review of shock-absorbing flooring for fall-related injury prevention.BMC geriatrics · 2022Pooled it
- Validation of a Deficit-Accumulation Frailty Index in the ASPirin in Reducing Events in the Elderly Study and Its Predictive Capacity for Disability-Free Survival.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Trial
- Circulating extracellular vesicles in plasma carry accessible molecular signatures of aging in mice.bioRxiv : the preprint server for biology · 2026Article
- The association of frailty with age and lifespan in mice differs by strain and sex.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- High frailty index scores predict mortality and changes in blood-based biomarkers in aging female mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Bat-Inspired Longevity: Immune Damage Management and Nutritional Modulation for Healthy Aging.International journal of molecular sciences · 2026Review
- The rise and deceleration of neuronal excitability in aging and Alzheimer's disease: Mechanisms, implications, and therapeutic targets.Ageing research reviews · 2026Review
- Associations of physical activity domains and delayed biological aging: assessing heterogeneity and interaction of effects.Biology of sport · 2026Article
- Biological aging mediates and frailty modifies the associations of arterial stiffness with incident probable sarcopenia and sarcopenia: a prospective cohort study of UK biobank.Frontiers in public health · 2026Article
- Artificial intelligence approaches in biological age prediction: current status and challenges.British journal of biomedical science · 2026Review
- Molecular markers, mechanisms and metrics of biological aging: a scoping review.Frontiers in aging · 2026Review
- Review
- DNA methylation signatures of frailty beyond age: a longitudinal study of female and male mice.bioRxiv : the preprint server for biology · 2025Article
- A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine.Scientific reports · 2025Article
- Age-dependent effects of exercise on gut microbiota-mitochondria axis and cognitive function in aging mice.Journal of exercise rehabilitation · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the heterogeneity in health of older adults is a compelling question in the biology of aging. We analyzed the performance of five measures of health heterogeneity, judging them by their ability to predict mortality. Using clinical and biomarker data on 1,013 participants of the Canadian Study of Health and Aging who were followed for up to 6 years, we calculated two indices of biological age using the Klemera and Doubal method, which controversially includes using chronological age as a "biomarker," and three frailty indices (FIs) that do not include chronological age: a standard clinical FI, an FI from standard laboratory blood tests and blood pressure, and their combination (FI-combined). Predictive validity was tested using Cox proportional hazards analysis and discriminative ability by the area under the receiver-operating characteristic curves. All five measures showed moderate performance that was improved by combining measures to evaluate larger numbers of items. The greatest addition in explanatory power came from the FI-combined that showed the best mortality prediction in an age-adjusted model. More extensive comparisons across different databases are required, but these results do not support including chronological age as a biomarker.
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