ArticleMolecular systems biology2016
Slowdown of growth controls cellular differentiation.
Article in Molecular systems biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Modulation of the Sporulation Dynamics in the Plant-Probiotic Bacillus velezensis 83 via Carbon and Quorum-Sensing Metabolites.Probiotics and antimicrobial proteins · 2025Article
- Changes in Spo0A~P pulsing frequency control biofilm matrix deactivation.PLoS computational biology · 2025Article
- Biophysical modeling reveals the transcriptional regulatory mechanism of Spo0A, the master regulator in starvingmSystems · 2025Article
- Unique growth and morphology properties of Clade 5bioRxiv : the preprint server for biology · 2025Article
- Unique growth and morphology properties of Clade 5 Clostridioides difficile strains revealed by single-cell time-lapse microscopy.PLoS pathogens · 2025Article
- Regulation of biofilm gene expression by DNA replication in Bacillus subtilis.Journal of cellular and molecular medicine · 2024Article
- Review
- The motility-matrix production switch inJournal of bacteriology · 2024Article
- The σB alternative sigma factor circuit modulates noise to generate different types of pulsing dynamics.PLoS computational biology · 2023Article
- Article
- Dynamic gene expression and growth underlie cell-to-cell heterogeneity inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Rampant loss of social traits during domestication of a Bacillus subtilis natural isolate.Scientific reports · 2020Article
- Artificial Sporulation Induction (ASI) byInternational journal of molecular sciences · 2020Article
- Optogenetic control of Bacillus subtilis gene expression.Nature communications · 2019Article
- Differentiation of Vegetative Cells into Spores: a Kinetic Model Applied to Bacillus subtilis.Applied and environmental microbiology · 2019Article
- Escherichia coli can survive stress by noisy growth modulation.Nature communications · 2018Article
- Role of metabolic spatiotemporal dynamics in regulating biofilm colony expansion.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Noise in a phosphorelay drives stochastic entry into sporulation inThe EMBO journal · 2017Article
- The PAS domains of the major sporulation kinase in Bacillus subtilis play a role in tetramer formation that is essential for the autokinase activity.MicrobiologyOpen · 2017Article
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Authors and funding
6 authors.
Funding
Abstract
How can changes in growth rate affect the regulatory networks behavior and the outcomes of cellular differentiation? We address this question by focusing on starvation response in sporulating Bacillus subtilis We show that the activity of sporulation master regulator Spo0A increases with decreasing cellular growth rate. Using a mathematical model of the phosphorelay-the network controlling Spo0A-we predict that this increase in Spo0A activity can be explained by the phosphorelay protein accumulation and lengthening of the period between chromosomal replication events caused by growth slowdown. As a result, only cells growing slower than a certain rate reach threshold Spo0A activity necessary for sporulation. This growth threshold model accurately predicts cell fates and explains the distribution of sporulation deferral times. We confirm our predictions experimentally and show that the concentration rather than activity of phosphorelay proteins is affected by the growth slowdown. We conclude that sensing the growth rates enables cells to indirectly detect starvation without the need for evaluating specific stress signals.
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