ArticleMedical decision making : an international journal of the Society for Medical Decision Making2017
Side Effect Perceptions and Their Impact on Treatment Decisions in Women.
Article in Medical decision making : an international journal of the Society for Medical Decision Making, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Variability in Affect and Willingness to Take Medication.Medical decision making : an international journal of the Society for Medical Decision Making · 2018Trial
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- Application of Fuzzy AHP for Medication Decision Making in Iron-Chelating Medications for Thalassemia.Pharmacy (Basel, Switzerland) · 2025Article
- How are mental representations of asthma triggers and symptoms related to interpersonal risk perceptions? A psychometric investigation of caregivers of children with asthma.Psychology & health · 2025Article
- Patient Perceptions of Radiation Therapy Prior to Initial Consultation With a Radiation Oncologist.Advances in radiation oncology · 2025Article
- COVID-19 vaccine refusal is driven by deliberate ignorance and cognitive distortions.NPJ vaccines · 2024Article
- No action is without its side effects: Adverse drug reactions and missed doses of antituberculosis therapy, a scoping review.British journal of clinical pharmacology · 2024Article
- Determination of factors influencing young adults' intention to have COVID-19 vaccine in the Philippines: An integration of Health Belief Model and the Theory of Planned Behavior.Public health in practice (Oxford, England) · 2023Article
- Young adult preference analysis on the attributes of COVID-19 vaccine in the Philippines: A conjoint analysis approach.Public health in practice (Oxford, England) · 2022Article
- Using a Foreign Language Changes Medical Judgments of Preventative Care.Brain sciences · 2021Article
- Understanding Decision Making about Breast Cancer Prevention in Action: The Intersection of Perceived Risk, Perceived Control, and Social Context: NRG Oncology/NSABP DMP-1.Medical decision making : an international journal of the Society for Medical Decision Making · 2019Article
- Switching control strategy for the HIV dynamic system with some unknown parameters.IET systems biology · 2019Article
- Effects of Emotion on Medical Decisions Involving Tradeoffs.Medical decision making : an international journal of the Society for Medical Decision Making · 2018Article
- Spontaneous mental associations with the words "side effect": Implications for informed and shared decision making.Patient education and counseling · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundSide effects prompt some patients to forego otherwise-beneficial therapies. This study explored which characteristics make side effects particularly aversive.
methodsWe used a psychometric approach, originating from research on risk perception, to identify the factors (or components) underlying side effect perceptions. Women ( N = 149) aged 40 to 74 years were recruited from a patient registry to complete an online experiment. Participants were presented with hypothetical scenarios in which an effective and necessary medication conferred a small risk of a single side effect (e.g., nausea, dizziness). They rated a broad range of side effects on several characteristics (e.g., embarrassing, treatable). In addition, we collected 4 measures of aversiveness for each side effect: choosing to take the medication, willingness to pay to avoid the side effect (WTP), negative affective attitude associated with the side effect, and how each side effect ranks among others in terms of undesirability. A principal components analysis (PCA) was used to identify the components underlying side effect perceptions. Then, for each aversiveness measure separately, regression analyses were used to determine which components predicted differences in aversiveness among the side effects.
resultsThe PCA revealed 4 components underlying side effect perceptions: affective challenge (e.g., frightening), social challenge (e.g., disfiguring), physical challenge (e.g., painful), and familiarity (e.g., common). Side effects perceived as affectively and physically challenging elicited the highest levels of aversiveness across all 4 measures.
conclusionsUnderstanding what side effect characteristics are most aversive may inform interventions to improve medical decisions and facilitate the translation of novel biomedical therapies into clinical practice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.