Evidence map›Paper›PMID 27216490›Full record

ArticleBMC public health2016

The health gains and cost savings of dietary salt reduction interventions, with equity and age distributional aspects.

Nhung Nghiem, Tony Blakely, Linda J Cobiac, Christine L Cleghorn, Nick Wilson

Abstract read
In one paragraph

Article in BMC public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  9. Role of dietary potassium and salt substitution in the prevention and management of hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nhung NghiemUniversity of Otago, PO Box 7343, Wellington, Wellington South, New Zealand.
Tony BlakelyUniversity of Otago, PO Box 7343, Wellington, Wellington South, New Zealand.
Linda J CobiacBritish Heart Foundation Centre on Population Approaches to NCD Prevention, Oxford University, Oxford, UK.
Christine L CleghornUniversity of Otago, PO Box 7343, Wellington, Wellington South, New Zealand.
Nick WilsonUniversity of Otago, PO Box 7343, Wellington, Wellington South, New Zealand. nick.wilson@otago.ac.nz.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA "diet high in sodium" is the second most important dietary risk factor for health loss identified in the Global Burden of Disease Study 2013. We therefore aimed to model health gains and costs (savings) of salt reduction interventions related to salt substitution and maximum levels in bread, including by ethnicity and age. We also ranked these four interventions compared to eight other modelled interventions.

methodsA Markov macro-simulation model was used to estimate QALYs gained and net health system costs for four dietary sodium reduction interventions, discounted at 3 % per annum. The setting was New Zealand (NZ) (2.3 million adults, aged 35+ years) which has detailed individual-level administrative cost data.

resultsThe health gain was greatest for an intervention where most (59 %) of the sodium in processed foods was replaced by potassium and magnesium salts. This intervention gained 294,000 QALYs over the remaining lifetime of the cohort (95 % UI: 238,000 to 359,000; 0.13 QALY per 35+ year old). Such salt substitution also produced the highest net cost-savings of NZ$ 1.5 billion (US$ 1.0 billion) (95 % UI: NZ$ 1.1 to 2.0 billion). All interventions generated relatively larger per capita QALYs for men vs women and for the indigenous Māori population vs non-Māori (e.g., 0.16 vs 0.12 QALYs per adult for the 59 % salt substitution intervention). Of relevance to workforce productivity, in the first 10 years post-intervention, 22 % of the QALY gain was among those aged <65 years (and 37 % for those aged <70).

conclusionsThe benefits are consistent with the international literature, with large health gains and cost savings possible from some, but not all, sodium reduction interventions. Health gain appears likely to occur among working-age adults and all interventions contributed to reducing health inequalities.

Indexed as

AdultAgedAge DistributionCardiovascular DiseasesCost-Benefit AnalysisCost SavingsDietFast FoodsFemaleHumansMagnesium CompoundsMaleMarkov ChainsMiddle AgedModels, TheoreticalNew ZealandMagnesium CompoundsPotassium CompoundsSodium Chloride, DietaryBreadCardiovascular diseaseDietary saltModellingSalt substitutionSodium

Identifiers

PMID27216490
PMCPMC4877955

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.