ArticleBMC bioinformatics2016
Efficient analysis of large datasets and sex bias with ADMIXTURE.
Article in BMC bioinformatics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
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- Revealing the range of equally likely estimates in the admixture model.G3 (Bethesda, Md.) · 2025Article
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- Population genomics of post-glacial western Eurasia.Nature · 2024Article
- Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations.Nature · 2024Article
- Identity-by-descent-based estimation of the X chromosome effective population size with application to sex-specific demographic history.G3 (Bethesda, Md.) · 2023Article
- The meaning of wild: Genetic and adaptive consequences from large-scale releases of domestic mallards.Communications biology · 2023Article
- Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings.PLoS genetics · 2023Article
- Using the UK Biobank as a global reference of worldwide populations: application to measuring ancestry diversity from GWAS summary statistics.Bioinformatics (Oxford, England) · 2022Article
- Genome-Wide Detection of Copy Number Variations and Evaluation of Candidate Copy Number Polymorphism Genes Associated With Complex Traits of Pigs.Frontiers in veterinary science · 2022Article
- Exploring the Effects of Mitonuclear Interactions on Mitochondrial DNA Gene Expression in Humans.Frontiers in genetics · 2022Article
- Summix: A method for detecting and adjusting for population structure in genetic summary data.American journal of human genetics · 2021Article
- Range reduction of Oblong Rocksnail,PeerJ · 2020Article
- Admixture mapping identifies genetic regions associated with blood pressure phenotypes in African Americans.PloS one · 2020Article
- GRAF-pop: A Fast Distance-Based Method To Infer Subject Ancestry from Multiple Genotype Datasets Without Principal Components Analysis.G3 (Bethesda, Md.) · 2019Article
- Analysis of biogeographic ancestry reveals complex genetic histories for indigenous communities of St. Vincent and Trinidad.American journal of physical anthropology · 2019Article
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4 authors.
Funding
Abstract
backgroundA number of large genomic datasets are being generated for studies of human ancestry and diseases. The ADMIXTURE program is commonly used to infer individual ancestry from genomic data.
resultsWe describe two improvements to the ADMIXTURE software. The first enables ADMIXTURE to infer ancestry for a new set of individuals using cluster allele frequencies from a reference set of individuals. Using data from the 1000 Genomes Project, we show that this allows ADMIXTURE to infer ancestry for 10,920 individuals in a few hours (a 5 × speedup). This mode also allows ADMIXTURE to correctly estimate individual ancestry and allele frequencies from a set of related individuals. The second modification allows ADMIXTURE to correctly handle X-chromosome (and other haploid) data from both males and females. We demonstrate increased power to detect sex-biased admixture in African-American individuals from the 1000 Genomes project using this extension.
conclusionsThese modifications make ADMIXTURE more efficient and versatile, allowing users to extract more information from large genomic datasets.
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