ArticleBMC cardiovascular disorders2016
A comparative study of time-specific oxidative stress after acute myocardial infarction in patients with and without diabetes mellitus.
Article in BMC cardiovascular disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Alpha-Lipoic Acid as a Means of Influence on Systemic Inflammation in Type 2 Diabetes Mellitus Patients with Prior Myocardial Infarction.Journal of medicine and lifeTrial
- Role of Plant-Derived Antioxidants in Oxidative Stress-Associated Myocardial Infarction: Structure-Activity Relationship (SAR)-Based Mechanistic Insights.Molecules (Basel, Switzerland) · 2026Review
- Association between SHR and mortality in critically ill patients with CVD: a retrospective analysis and machine learning approach.Diabetology & metabolic syndrome · 2025Article
- Correlation between stress-induced hyperglycemia and postoperative acute kidney injury in nondiabetic patients who underwent acute type A aortic dissection surgery: A retrospective observational study.The Journal of international medical research · 2025Observational
- Stress Hyperglycemia Ratio Outperforms Glycemic Variability in Predicting Mortality Among Acute Myocardial Infarction Patients With Reduced Ejection Fraction: A Retrospective Cohort Study.Journal of diabetes · 2025Article
- Inflammatory Markers and Saphenous Vein Graft Stenosis: Insights into the Use of Glucose-to-Lymphocyte Ratio as a Prognostic Marker.Journal of clinical medicine · 2025Article
- The Role of Glucose-Lymphocyte Ratio in Evaluating the Severity of Coronary Artery Disease.Journal of clinical medicine · 2024Article
- Impact of stress hyperglycemia ratio on mortality in patients with critical acute myocardial infarction: insight from american MIMIC-IV and the chinese CIN-II study.Cardiovascular diabetology · 2023Article
- Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice.Journal of molecular and cellular cardiology · 2023Article
- Association between glucose-to-lymphocyte ratio and in-hospital mortality in acute myocardial infarction patients.PloS one · 2023Article
- The Prognostic Value of Derivatives-Reactive Oxygen Metabolites (d-ROMs) for Cardiovascular Disease Events and Mortality: A Review.Antioxidants (Basel, Switzerland) · 2022Review
- Impact of admission hyperglycemia on short and long-term prognosis in acute myocardial infarction: MINOCA versus MIOCA.Cardiovascular diabetology · 2021Observational
- Hyperglycemia, inflammatory response and infarct size in obstructive acute myocardial infarction and MINOCA.Cardiovascular diabetology · 2021Observational
- The Key Genes Underlying Pathophysiology Association between Plaque Instability and Progression of Myocardial Infarction.Disease markers · 2021Article
- Serum oxidative stress is an independent prognostic marker in colorectal cancer.Translational cancer research · 2019Article
- High admission glucose levels predict worse short-term clinical outcome in non-diabetic patients with acute myocardial infraction: a retrospective observational study.BMC cardiovascular disorders · 2019Observational
- Advanced glycation end products in isoproterenol-induced acute myocardial infarction.Medicine and pharmacy reports · 2019Article
- Emerging Biomarkers of Oxidative Stress in Acute and Stable Coronary Artery Disease: Levels and Determinants.Antioxidants (Basel, Switzerland) · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
backgroundOxidative stress is involved in the initiation and progression of atherosclerosis, and hyperglycemia is known to increase oxidative stress, which injures the endothelium and accelerates atherosclerosis. To clarify the relation between oxidative stress, diabetes mellitus (DM), and acute myocardial infarction (AMI), we evaluated and compared time-specific oxidative stress after AMI in patients with and without DM by simple measurement of derivatives of reactive oxygen metabolites (d-ROMs) levels as indices of reactive oxygen species production.
methodsSixty-eight AMI patients were enrolled (34 non-DM patients and 34 DM patients). Using the FRAS4 free radical analytical system, we measured d-ROMs levels in each patient at two time points: 1 and 2 weeks after AMI onset.
resultsd-ROM levels decreased significantly between week 1 and week 2 (from 475.4 ± 119.4 U.CARR to 367.7 ± 87.9 U.CARR, p < 0.001) in the non-DM patients but did not change in the DM patients (from 463.1 ± 109.3 U.CARR to 461.7 ± 126.8 U.CARR, p = 0.819). Moreover, significant correlation was found in the total patient group between d-ROMs levels at 1 week and N-terminal prohormone of brain natriuretic peptide (r = 0.376, p = 0.041) and between d-ROM levels at 2 weeks and 2-hour oral glucose tolerance test glucose levels (r = 0.434, p < 0.001).
conclusionsExposure to oxidative stress is greater in AMI patients with DM than AMI patients without DM. Our study results suggest that it is the continuous hyperglycemia that increases oxidative stress in these patients, causing endothelial dysfunction and accelerating atherosclerosis. However, long-term follow up study is needed to assess whether the increased oxidative stress affects patient outcomes.
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