ReviewNeuroradiology2016
Non-ischemic cerebral enhancing lesions secondary to endovascular aneurysm therapy: nickel allergy or foreign body reaction? Case series and review of the literature.
Review in Neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Non-Ischemic Cerebral Enhancing (NICE) lesions after flow diversion for intracranial aneurysms: a systematic review with case-level synthesis.BMC neurology · 2026Pooled it
- Outcomes, complications, and management in flow diverter treatment of cerebral aneurysms: a 15-year single-center experience.Neuroradiology · 2026Article
- Delayed non ischemic cerebral enhancing lesions after endovascular stent assisted coiling of an unruptured intracranial aneurysm, a case description followed by a literature analysis on the probable causes, differential diagnosis and treatment.Quantitative imaging in medicine and surgery · 2025Article
- A novel approach to nickel allergy in neurointerventional surgery: Peripheral arterial stent testing protocol to guide the choice of cerebral aneurysm treatment.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Hydrophilic Polymer Embolism: An Underappreciated Complication of Endovascular Procedures that Physicians Should be Aware Of.Cardiovascular and interventional radiology · 2025Review
- Investigation of the Neurotoxicity Mechanisms of NiInternational journal of molecular sciences · 2025Article
- Cerebral foreign body reaction (CFBR) after endovascular treatments is a rare event to be aware of: case series and review of literature.Journal of neurology · 2025Review
- Article
- Long-term follow-up of patients with non-ischemic cerebral enhancing lesions following endovascular aneurysm treatment: magnetic resonance imaging findings, clinical course, and treatment.Therapeutic advances in neurological disorders · 2025Article
- Non-ischemic cerebral enhancing (NICE) lesions after flow diversion for intracranial aneurysms: a multicenter study.Journal of neurointerventional surgery · 2024Article
- NICE lesions: an uncommon cause of stroke mimic following intracranial aneurysm embolization.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Human stem cell-derived neurons and astrocytes to detect novel auto-reactive IgG response in immune-mediated neurological diseases.Frontiers in immunology · 2024Article
- Endovascular Treatment of Cerebrovascular Lesions Using Nickel- or Nitinol-Containing Devices in Patients with Nickel Allergies.AJNR. American journal of neuroradiology · 2023Article
- Delayed Leucoencephalopathy as a Complication after Endovascular Therapy of Intracranial Aneurysms-A Case Series.Journal of clinical medicine · 2023Article
- Non-ischemic cerebral enhancing lesions after thrombectomy: a multicentric retrospective French national registry.Neuroradiology · 2022Article
- Incidence, clinical spectrum, and immunotherapy of non-ischemic cerebral enhancing lesions after endovascular therapy.Therapeutic advances in neurological disorders · 2022Article
- Hydrophilic polymer embolization following flow diversion of cerebral aneurysms.The neuroradiology journal · 2021Review
- Delayed Leukoencephalopathy and Foreign Body Reaction After Endovascular Treatment in Patients With Intracranial Aneurysms and Aneurysmal Subarachnoid Hemorrhage-A Systematic Review of the Literature.Frontiers in surgery · 2021Article
- Microcatheter Originating Debris during Neuroendovascular Procedures: Mechanism of Dislodgement and Its Prevention.AJNR. American journal of neuroradiology · 2020Article
- Delayed Leukoencephalopathy: A Rare Complication after Coiling of Cerebral Aneurysms.AJNR. American journal of neuroradiology · 2020Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDelayed onset of non-ischemic cerebral enhancing (NICE) lesions is a rare complication of intracranial aneurysms' endovascular therapy (EVT). The purpose of this study is to report this rare complication and its potential pathophysiology in a single-center case series and review the relevant literature.
methodsAfter retrospective review of all patients managed by EVT at our institution from January 1, 2012 to December 31, 2014, 2 out of 374 patients (0.5 %) with such a complication were identified. Skin patch testing was performed with all endovascular devices used in the two patients and with the European baseline series, including nickel. All previously published cases in the English literature were reviewed based on exhaustive PubMed and Embase research.
resultsPatient no. 1 developed NICE lesions 1 month after balloon-assisted coiling of a ruptured anterior communicating artery aneurysm. Patient no. 2 developed NICE lesions 12 months (the longest delay reported to date for such a complication) after the treatment of a right carotid-ophthalmic aneurysm by loose coiling and flow diversion. Patient no. 2 demonstrated nickel skin reactivity, but none of the two patients presented allergic reaction to the devices used during interventions.
conclusionsBased on our observations and review of the literature, we hypothesize that delayed non-ischemic cerebral enhancing lesions after EVT are more likely related to foreign body emboli rather than nickel allergy. The two presented cases demonstrate the potential for recurrence and prolonged fluctuation of NICE lesions, warranting long-term follow-up for all patients presenting this complication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.