Evidence map›Paper›PMID 27216049›Full record

ArticleAntimicrobial agents and chemotherapy2016

In Vitro Synergism between Azithromycin or Terbinafine and Topical Antimicrobial Agents against Pythium insidiosum.

Sabrina R Itaqui, Camila M Verdi, Juliana S M Tondolo, Thaisa S da Luz, Sydney H Alves, Janio M Santurio, Érico S Loreto

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Melaleuca alternifolia formulations in the treatment of experimental pythiosis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022
    Article
  4. Review
  5. A Review: Antimicrobial Therapy for Human Pythiosis.Antibiotics (Basel, Switzerland) · 2022
    Review
  6. Review
  7. Article
  8. The effect of fennel essential oil andPostepy dermatologii i alergologii · 2019
    Article
  9. Antimicrobial agents and chemotherapy · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sabrina R ItaquiPrograma de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria (UFSM), Rio Grande do Sul, Brazil.
Camila M VerdiPrograma de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria (UFSM), Rio Grande do Sul, Brazil.
Juliana S M TondoloPrograma de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria (UFSM), Rio Grande do Sul, Brazil.
Thaisa S da LuzPrograma de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria (UFSM), Rio Grande do Sul, Brazil.
Sydney H AlvesPrograma de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria (UFSM), Rio Grande do Sul, Brazil.
Janio M SanturioPrograma de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria (UFSM), Rio Grande do Sul, Brazil.
Érico S LoretoPrograma de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria (UFSM), Rio Grande do Sul, Brazil erico.loreto@gmail.com.
Universidade Federal de Santa Maria · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe here in vitro activity for the combination of azithromycin or terbinafine and benzalkonium, cetrimide, cetylpyridinium, mupirocin, triclosan, or potassium permanganate. With the exception of potassium permanganate, the remaining antimicrobial drugs were active and had an MIC90 between 2 and 32 μg∕ml. The greatest synergism was observed for the combination of terbinafine and cetrimide (71.4%). In vivo experimental evaluations will clarify the potential of these drugs for the topical treatment of lesions caused by Pythium insidiosum.

Indexed as

Anti-Infective AgentsAzithromycinBenzalkonium CompoundsCetrimoniumCetrimonium CompoundsCetylpyridiniumDrug InteractionsDrug SynergismDrug Therapy, CombinationMicrobial Sensitivity TestsMupirocinNaphthalenesPotassium PermanganatePythiumTerbinafineTriclosanAnti-Infective AgentsAzithromycinBenzalkonium CompoundsCetrimoniumCetrimonium CompoundsCetylpyridiniumMupirocinNaphthalenesPotassium PermanganateTerbinafineTriclosan

Identifiers

PMID27216049
PMCPMC4958184
OpenAlexW2407472147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.