ArticleScientific reports2016
Protons at the speed of sound: Predicting specific biological signaling from physics.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Contribution of the Collective Excitations to the Coupled Proton and Energy Transport along Mitochondrial Cristae Membrane in Oxidative Phosphorylation System.Entropy (Basel, Switzerland) · 2022Article
- Acetylcholinesterase Activity Influenced by Lipid Membrane Area and Surface Acoustic Waves.Micromachines · 2022Article
- Lipid Membrane State Change by Catalytic Protonation and the Implications for Synaptic Transmission.Membranes · 2021Article
- Nonlinear pulses at the interface and its relation to state and temperature.The European physical journal. E, Soft matter · 2020Article
- Acoustic Waves in Axonal Membrane and Caveolins are the New Targets for Pain Treatment with High Frequency Ultrasound.Journal of pain research · 2020Article
- Ultrasound Neuromodulation: A Review of Results, Mechanisms and Safety.Ultrasound in medicine & biology · 2019Review
- It sounds like an action potential: unification of electrical, chemical and mechanical aspects of acoustic pulses in lipids.Journal of the Royal Society, Interface · 2019Article
- Similarities between action potentials and acoustic pulses in a van der Waals fluid.Scientific reports · 2019Article
- Collision and annihilation of nonlinear sound waves and action potentials in interfaces.Journal of the Royal Society, Interface · 2018Article
- Cell Surface Deformation during an Action Potential.Biophysical journal · 2018Article
- Long range physical cell-to-cell signalling via mitochondria inside membrane nanotubes: a hypothesis.Theoretical biology & medical modelling · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Local changes in pH are known to significantly alter the state and activity of proteins and enzymes. pH variations induced by pulses propagating along soft interfaces (e.g. membranes) would therefore constitute an important pillar towards a physical mechanism of biological signaling. Here we investigate the pH-induced physical perturbation of a lipid interface and the physicochemical nature of the subsequent acoustic propagation. Pulses are stimulated by local acidification and propagate - in analogy to sound - at velocities controlled by the interface's compressibility. With transient local pH changes of 0.6 directly observed at the interface and velocities up to 1.4 m/s this represents hitherto the fastest protonic communication observed. Furthermore simultaneously propagating mechanical and electrical changes in the lipid interface are detected, exposing the thermodynamic nature of these pulses. Finally, these pulses are excitable only beyond a threshold for protonation, determined by the pKa of the lipid head groups. This protonation-transition plus the existence of an enzymatic pH-optimum offer a physical basis for intra- and intercellular signaling via sound waves at interfaces, where not molecular structure and mechano-enyzmatic couplings, but interface thermodynamics and thermodynamic transitions are the origin of the observations.
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