Evidence map›Paper›PMID 27216016›Full record

ArticleClinical and experimental nephrology2017

Comparison of methods of steroid administration combined with tonsillectomy for IgA nephropathy patients.

Hirofumi Watanabe, Shin Goto, Daisuke Kondo, Takuma Takata, Hajime Yamazaki, Michihiro Hosojima, Suguru Yamamoto, Yoshikatsu Kaneko, Ryuji Aoyagi, Ichiei Narita

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Clinical and experimental nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Review
  5. Observational
  6. Galactosylation of IgA1 Is Associated with Common Variation inJournal of the American Society of Nephrology : JASN · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Hirofumi WatanabeDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuoku, Niigata, Niigata, 951-8510, Japan.
Shin GotoDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuoku, Niigata, Niigata, 951-8510, Japan. gotos@med.niigata-u.ac.jp.
Daisuke KondoDepartment of Nephrology and Rheumatology, Niigata City General Hospital, Niigata, Japan.
Takuma TakataDepartment of Nephrology, Nagaoka Chuo General Hospital, Nagaoka, Japan.
Hajime YamazakiDepartment of Internal Medicine, Nagaoka Red Cross Hospital, Nagaoka, Japan.
Michihiro HosojimaDepartment of Clinical Nutrition Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Suguru YamamotoDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuoku, Niigata, Niigata, 951-8510, Japan.
Yoshikatsu KanekoDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuoku, Niigata, Niigata, 951-8510, Japan.
Ryuji AoyagiDepartment of Nephrology, Tachikawa General Hospital, Nagaoka, Japan.
Ichiei NaritaDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuoku, Niigata, Niigata, 951-8510, Japan.
Niigata University Medical and Dental Hospital · JPNagaoka Red Cross Hospital · JPNiigata City General Hospital · JPNiigata University · JPTachikawa Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIgA nephropathy (IgAN) is a chronic glomerular disease that causes end-stage renal disease in 20-40 % of patients within 20 years. The efficacy of tonsillectomy combined with steroid pulse (SP) administration (TSP) for clinical remission of IgAN has been reported. Particularly in Japan, TSP has been performed widely. However, the optimum method for steroid administration in TSP has not been established.

methodsWe retrospectively compared clinical remission in IgAN patients treated with tonsillectomy combined with two different steroid administration methods: (1) three courses of SP therapy and oral prednisolone administered on alternate days (group 3A; n = 25); and (2) one course of SP therapy and oral prednisolone administered on consecutive days (group 1C; n = 22).

resultsThere was no significant difference in the clinical remission rates between the two groups at 12 (48.0 vs. 40.9 %, P = 0.77) and 24 months after starting treatment (68.0 vs. 72.7 %, P = 0.76) and at the final observation (76.0 vs. 81.8 %, P = 0.73). The mean period from starting treatment to remission of hematuria in group 3A was significantly shorter than that in group 1C (5.7 ± 4.4 vs. 9.9 ± 5.9 months, P = 0.03). Dyslipidemic patients treated for the first time with statin after the SP therapy were more present in group 3A at 24 months (P = 0.02).

conclusionsIn IgAN patients, treatment of group 3A may be effective for inducing rapid remission of hematuria. Further studies are needed to establish an appropriate protocol for TSP.

Indexed as

TonsillectomyAdministration, IntravenousAdministration, OralAdultCombined Modality TherapyFemaleGlomerulonephritis, IGAGlucocorticoidsHumansMaleMethylprednisolonePulse Therapy, DrugRemission InductionRetrospective StudiesTime FactorsTreatment OutcomeGlucocorticoidsMethylprednisoloneIgA nephropathySteroid pulse therapyTonsillectomyTreatment protocol

Identifiers

PMID27216016
OpenAlexW2400917562

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.