Evidence map›Paper›PMID 27215704›Full record

ArticleHuman vaccines & immunotherapeutics2016

What timing of vaccination is potentially dangerous for children younger than 2 years?

Pauline Gras, Anne-Charlotte Bailly, Marion Lagrée, Benoit Dervaux, Alain Martinot, François Dubos

Open access · bronzeAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Pauline Grasa Univ. Lille, CHU Lille, Pediatric Emergency Unit & Infectious Diseases , Lille , France.
Anne-Charlotte Baillya Univ. Lille, CHU Lille, Pediatric Emergency Unit & Infectious Diseases , Lille , France.
Marion Lagréea Univ. Lille, CHU Lille, Pediatric Emergency Unit & Infectious Diseases , Lille , France.
Benoit Dervauxc Univ. Lille, CHU Lille , Department of Economy & Management , Lille , France.
Alain Martinota Univ. Lille, CHU Lille, Pediatric Emergency Unit & Infectious Diseases , Lille , France.
François Dubosa Univ. Lille, CHU Lille, Pediatric Emergency Unit & Infectious Diseases , Lille , France.
Centre Hospitalier Universitaire de Lille · FRUniversité de Lille · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccine-preventable diseases still occur although measured coverage rates at 2 y of age are high. The occurrence of these diseases may be explained in part by untimely, that is, late vaccination. Our objective was to identify potentially dangerous vaccination delays for each dose of each vaccine in children younger than 2 y. A 3-round Delphi process was conducted by e-mail. We recruited 37 French experts in vaccines for children: 16 from the Infovac-France group and 21 from the French study group for pediatric infectious diseases. Items were generated by a literature review for the 10 vaccine doses recommended before 2 y of age. Item reduction in round 1 and 2 and any consensus in round 3 used a 70% consensus cutoff. The mean participation rate was 79%. Delays that should not be exceeded were identified for all vaccine doses. The 70% consensus was reached for 6 of the 10 vaccine doses: 15 d after the recommended date for the first 2 doses of the diphtheria-tetanus-acellular pertussis-inactivated polio vaccine/Haemophilus influenzae b vaccine and for the second dose of the pneumococcal conjugate vaccine, 1 month for the meningococcal C vaccine and for the first dose of the measles-mumps-rubella vaccine, and 11 y of age for completion of the hepatitis B vaccination. This Delphi process identified potentially dangerous vaccination delays for children to the age of 2 y. These can be used as new indicators in further studies of vaccine effectiveness and can help to improve the quality of vaccine protection in children.

Indexed as

Age FactorsImmunization ScheduleFranceHumansInfantInfant, NewbornVaccinesVaccineschildrendangerous delayepidemiologyinfectious diseasespediatricstimelinessvaccine

Identifiers

PMID27215704
PMCPMC4994719
OpenAlexW2402009470

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.