Evidence map›Paper›PMID 27215679›Full record

ReviewClinical science (London, England : 1979)2016

Sex hormone therapy and progression of cardiovascular disease in menopausal women.

Rabe E Alhurani, C Anwar A Chahal, Ahmed T Ahmed, Essa A Mohamed, Virginia M Miller

Abstract readReview
In one paragraph

Review in Clinical science (London, England : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. In search of elixir: Pharmacological agents against stem cell senescence.Iranian journal of basic medical sciences · 2021
    Review
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rabe E AlhuraniMayo Clinic Graduate School of Medicine, Rochester, MN 55905, U.S.A. Department of Neurology, Mayo Clinic, Rochester, MN 55905, U.S.A.
C Anwar A ChahalMayo Clinic Graduate School of Medicine, Rochester, MN 55905, U.S.A. Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, U.S.A.
Ahmed T AhmedMayo Clinic Graduate School of Medicine, Rochester, MN 55905, U.S.A. Division of Preventive, Occupational and Aerospace Medicine, Mayo Clinic, Rochester, MN 55905, U.S.A.
Essa A MohamedMayo Clinic Graduate School of Medicine, Rochester, MN 55905, U.S.A.
Virginia M MillerDepartment of Surgery, Mayo Clinic, Rochester, MN, U.S.A. Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, U.S.A. miller.virginia@mayo.edu.
Mayo Clinic · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's DiseaseU54AG044170 · NIA · MAYO CLINIC ROCHESTER · PI KAPOOR, EKTA · 2018 to 2022
$7.7M
Sex-specific Risk for Vascular Dysfunction and Cognitive DeclineP50AG044170 · NIA · MAYO CLINIC ROCHESTER · PI MILLER, VIRGINIA M · 2012 to 2017
$6.1M
NCATS NIH HHS UL1 TR000135NIA NIH HHS P50 AG044170NIA NIH HHS U54 AG044170
6 · The paper itself

Abstract

One of the most controversial health decisions facing women is deciding upon the use of hormonal treatments for symptoms of menopause. This brief review focuses on the historical context of use of menopausal hormone treatments (MHT), summarizes results of major observational, primary and secondary prevention studies of MHT and cardiovascular (CV) outcomes, provides evidence for how sex steroids modulate CV function and identifies challenges for future research. As medicine enters an era of personalization of treatment options, additional research into sex differences in the aetiology of CV diseases will lead to better risk identification for CV disease in women and identify whether a woman might receive CV benefit from specific formulations and doses of MHT.

Indexed as

Estrogen Replacement TherapyAnimalsCardiovascular DiseasesDisease ProgressionEstrogensGonadal Steroid HormonesHumansMenopauseEstrogensGonadal Steroid Hormones17 β-oestradiolatherosclerosiscarotid intima-medial thicknessconjugated equine oestrogenscoronary artery calcification

Identifiers

PMID27215679
PMCPMC5316470
OpenAlexW2401445523

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.