Evidence map›Paper›PMID 27215677›Full record

ReviewClinical science (London, England : 1979)2016

COPD and stroke: are systemic inflammation and oxidative stress the missing links?

Victoria Austin, Peter J Crack, Steven Bozinovski, Alyson A Miller, Ross Vlahos

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical science (London, England : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Chronic Obstructive Pulmonary Disease and the Risk of Stroke.Annals of the American Thoracic Society · 2017
    Pooled it
  4. Is COPD associated with alterations in hearing? A systematic review and meta-analysis.International journal of chronic obstructive pulmonary disease
    Pooled it
  5. Pooled it
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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Victoria AustinSchool of Health and Biomedical Sciences, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia.
Peter J CrackDepartment of Pharmacology and Therapeutics, The University of Melbourne, Parkville, VIC 3010, Australia.
Steven BozinovskiSchool of Health and Biomedical Sciences, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia Lung Health Research Centre, Department of Pharmacology & Therapeutics, The University of Melbourne, Parkville, VIC 3010, Australia.
Alyson A MillerSchool of Health and Biomedical Sciences, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia.
Ross VlahosSchool of Health and Biomedical Sciences, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia Lung Health Research Centre, Department of Pharmacology & Therapeutics, The University of Melbourne, Parkville, VIC 3010, Australia ross.vlahos@rmit.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and loss of lung function, and is currently the third largest cause of death in the world. It is now well established that cardiovascular-related comorbidities such as stroke contribute to morbidity and mortality in COPD. The mechanisms linking COPD and stroke remain to be fully defined but are likely to be interconnected. The association between COPD and stroke may be largely dependent on shared risk factors such as aging and smoking, or the association of COPD with traditional stroke risk factors. In addition, we propose that COPD-related systemic inflammation and oxidative stress may play important roles by promoting cerebral vascular dysfunction and platelet hyperactivity. In this review, we briefly discuss the pathogenesis of COPD, acute exacerbations of COPD (AECOPD) and cardiovascular comorbidities associated with COPD, in particular stroke. We also highlight and discuss the potential mechanisms underpinning the link between COPD and stroke, with a particular focus on the roles of systemic inflammation and oxidative stress.

Indexed as

AnimalsHumansInflammationOxidative StressPulmonary Disease, Chronic ObstructiveRisk FactorsSmokingStrokecardiovascular diseasechronic obstructive pulmonary disease (COPD)comorbiditiesoxidative stressstrokesystemic inflammation

Identifiers

PMID27215677
PMCPMC4876483

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.