ReviewCurrent pain and headache reports2016
Spreading Depression in Primary and Secondary Headache Disorders.
Review in Current pain and headache reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Systematic review of late-onset aura related to migraine: an overlooked phenomenon.Acta neurologica Belgica · 2025Pooled it
- Is headache a risk factor for dementia? A systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Tracking tDCS induced grey matter changes in episodic migraine: a randomized controlled trial.The journal of headache and pain · 2021Trial
- Saliva molecular inflammatory profiling in female migraine patients responsive to adjunctive cervical non-invasive vagus nerve stimulation: the MOXY Study.Journal of translational medicine · 2019Trial
- State-of-the-art preclinical techniques to study the impact of spreading depolarizations in awake rodents.The journal of headache and pain · 2025Review
- Independent causal effect of migraines on Alzheimer's disease risk: a multivariate Mendelian randomization study.Frontiers in neurology · 2024Article
- Spreading Depolarizations Contribute to the Acute Behavior Deficits Associated With a Mild Traumatic Brain Injury in Mice.Journal of neurotrauma · 2024Article
- Headache secondary to nontraumatic brain hemorrhage: a single-center, retrospective clinical study.Archives of medical science : AMS · 2023Article
- Circulating Insulin-Like Growth Factor 1 Levels and Migraine Risk: A Mendelian Randomization Study.Neurology and therapy · 2022Article
- Inhibition of HSP90 Preserves Blood-Brain Barrier Integrity after Cortical Spreading Depression.Pharmaceutics · 2022Article
- Expert panel's guideline on cervicogenic headache: The Chinese Association for the Study of Pain recommendation.World journal of clinical cases · 2021Review
- Mitochondria in migraine pathophysiology - does epigenetics play a role?Archives of medical science : AMS · 2019Article
- Spreading depression as a preclinical model of migraine.The journal of headache and pain · 2019Review
- Behavioral and electrophysiological brain effects of aspartame on well-nourished and malnourished rats.Metabolic brain disease · 2019Article
- Mindfulness for female outpatients with chronic primary headaches: an internet-based bibliotherapy.European journal of translational myology · 2018Article
- Spotlight on cervical vagus nerve stimulation for the treatment of primary headache disorders: a review.Journal of pain research · 2018Review
- Understanding Spreading Depression from Headache to Sudden Unexpected Death.Frontiers in neurology · 2018Review
- Inhibition of the P2X7-PANX1 complex suppresses spreading depolarization and neuroinflammation.Brain : a journal of neurology · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewSpreading depression (SD) is a wave of simultaneous and near-complete depolarization of virtually all cells in brain tissue associated with a transient "depression" of all spontaneous or evoked electrical activity in the brain. SD is widely accepted as the pathophysiological event underlying migraine aura and may play a role in headache pathogenesis in secondary headache disorders such as ischemic stroke, subarachnoid or intracerebral hemorrhage, traumatic brain injury, and epilepsy. Here, we provide an overview of the pathogenic mechanisms and propose plausible hypotheses on the involvement of SD in primary and secondary headache disorders. RECENT
findingsSD can activate downstream trigeminovascular nociceptive pathways to explain the cephalgia in migraine, and possibly in secondary headache disorders as well. In healthy, well-nourished tissue (such as migraine), the intense transmembrane ionic shifts, the cell swelling, and the metabolic and hemodynamic responses associated with SD do not cause tissue injury; however, when SD occurs in metabolically compromised tissue (e.g., in ischemic stroke, intracranial hemorrhage, or traumatic brain injury), it can lead to irreversible depolarization, injury, and neuronal death. Recent non-invasive technologies to detect SDs in human brain injury may aid in the investigation of SD in headache disorders in which invasive recordings are not possible. SD explains migraine aura and progression of neurological deficits associated with other neurological disorders. Studying the nature of SD in headache disorders might provide pathophysiological insights for disease and lead to targeted therapies in the era of precision medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.