ArticleMolecular & cellular proteomics : MCP2016
Urinary Proteomics Yield Pathological Insights for Ureteropelvic Junction Obstruction.
Article in Molecular & cellular proteomics : MCP, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Urothelial protein expression in pediatric patients with ureteropelvic junction obstruction.Pediatric nephrology (Berlin, Germany) · 2026Article
- Defining the urine proteome in boys with posterior urethral valves: a pilot study.Frontiers in cell and developmental biology · 2026Article
- Advancing the state of the art in congenital obstructive uropathy.Nature reviews. Urology · 2025Article
- Expression of tissue fibrosis genes in congenitally obstructed pyeloureteral junction and biomarkers of renal damage.Central European journal of urology · 2024Article
- Current status and future directions of application of urine proteomics in neonatology.Frontiers in pediatrics · 2024Review
- Quantitative Mass Spectrometry Normalization in Urine Biomarker Analysis in Nephrotic Syndrome.Glomerular diseases · 2022Article
- Association between urinary biomarkers MMP-7/TIMP-2 and reduced renal function in children with ureteropelvic junction obstruction.PloS one · 2022Article
- Urine Biomarkers Combined With Ultrasound for the Diagnosis of Obstruction in Pediatric Hydronephrosis.Frontiers in pediatrics · 2021Article
- A novel urinary biomarker protein panel to identify children with ureteropelvic junction obstruction - A pilot study.Journal of pediatric urology · 2020Article
- Prenatal Hypoxia and Placental Oxidative Stress: Insights from Animal Models to Clinical Evidences.Antioxidants (Basel, Switzerland) · 2020Review
- Characterizing Patients with Recurrent Urinary Tract Infections in Vesicoureteral Reflux: A Pilot Study of the Urinary Proteome.Molecular & cellular proteomics : MCP · 2020Article
- Managing Ureteropelvic Junction Obstruction in the Young Infant.Frontiers in pediatrics · 2020Review
- Early detection of unilateral ureteral obstruction by desorption electrospray ionization mass spectrometry.Scientific reports · 2019Article
- Urinary biomarkers for renal tract malformations.Expert review of proteomics · 2016Review
- Comparison of Urinary Biomarkers in Diagnosis of Ureteropelvic Junction Obstruction and Differentiation from Nonobstructive Dilatation.Journal of Indian Association of Pediatric SurgeonsArticle
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Abstract
Prenatal hydronephrosis is a common condition that may spontaneously resolve after birth. However, this condition can result in renal damage and requires surgical correction in a number of cases. Preventing renal damage is paramount, but existing diagnostic technology is invasive, exposes infants to radiation, is costly, and is often indeterminate. A better understanding of the pathophysiology of renal obstruction as reflected in the urinary proteome may provide new insights into the disease that could potentially alter the clinical management of hydronephrosis. We performed a quantitative proteomics study of urine that was surgically obtained from eight clinically significant, unilaterally obstructed infants versus eight healthy controls, with the goal of identifying quantitatively varying proteins and the biological networks associated with them. Notably, urine was obtained from both the obstructed kidney and the bladder. Over 1100 proteins were identified, and a total of 76 quantitatively varying proteins were identified. Proteins involved in oxidative stress, inflammation, and renal disease pathways showed the most significant abundance differences. This study gives a deeper understanding of the critical proteomic changes associated with renal obstruction and represents the deepest proteomic profile of renal obstruction to date.
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