ArticleCritical care (London, England)2016
Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome.
Article in Critical care (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Thrombomodulin is associated with increased mortality and organ failure in mechanically ventilated children with acute respiratory failure: biomarker analysis from a multicenter randomized controlled trial.Critical care (London, England) · 2021Trial
- Dysregulated Coagulation and Fibrinolysis Are Present in Patients Admitted to the Emergency Department with Acute Hypoxemic Respiratory Failure: A Prospective Study.Biomedicines · 2024Article
- TM9SF1 offers utility as an efficient predictor of clinical severity and mortality among acute respiratory distress syndrome patients.Frontiers in immunology · 2024Article
- Article
- Nucleotide polymorphism in ARDS outcome: a whole exome sequencing association study.Annals of translational medicine · 2021Article
- Genetic justification of severe COVID-19 using a rigorous algorithm.Clinical immunology (Orlando, Fla.) · 2021Article
- Can Big Data and Machine Learning Improve Our Understanding of Acute Respiratory Distress Syndrome?Cureus · 2021Review
- Why COVID-19 is less frequent and severe in children: a narrative review.World journal of pediatrics : WJP · 2021Review
- Endothelial Damage in Acute Respiratory Distress Syndrome.International journal of molecular sciences · 2020Review
- Biomarkers in pediatric acute respiratory distress syndrome.Annals of translational medicine · 2019Review
- Precision Medicine and its Role in the Treatment of Sepsis: A Personalised View.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2019Review
- The Current State of Pediatric Acute Respiratory Distress Syndrome.Pediatric allergy, immunology, and pulmonology · 2019Review
- Anticoagulant therapy in acute respiratory distress syndrome.Annals of translational medicine · 2018Review
- Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome.The Lancet. Respiratory medicine · 2017Review
- A path to precision in the ICU.Critical care (London, England) · 2017Review
- Visit to intensive care of 2050.Intensive care medicine · 2017Article
- Anti-inflammatory Effects of Heme Oxygenase-1 Depend on Adenosine AFrontiers in immunology · 2017Article
- Angiopoietin-2 Levels as Predictors of Outcome in Mechanically Ventilated Patients with Acute Respiratory Distress Syndrome.Disease markers · 2017Observational
- Genomics and pharmacogenomics of sepsis: so close and yet so far.Critical care (London, England) · 2016Article
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12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAltered plasma levels of protein C, thrombomodulin, and the endothelial protein C receptor are associated with poor clinical outcomes in patients with acute respiratory distress syndrome (ARDS). We hypothesized that common variants in these genes would be associated with mortality as well as ventilator-free and organ failure-free days in patients with ARDS.
methodsWe genotyped linkage disequilibrium-based tag single-nucleotide polymorphisms in the ProteinC, Thrombomodulin and Endothelial Protein C Reptor Genes among 320 self-identified white patients of European ancestry from the ARDS Network Fluid and Catheter Treatment Trial. We then tested their association with mortality as well as ventilator-free and organ-failure free days.
resultsThe GG genotype of rs1042580 (p = 0.02) and CC genotype of rs3716123 (p = 0.002), both in the thrombomodulin gene, and GC/CC genotypes of rs9574 (p = 0.04) in the endothelial protein C receptor gene were independently associated with increased mortality. An additive effect on mortality (p < 0.001), ventilator-free days (p = 0.01), and organ failure-free days was observed with combinations of these high-risk genotypes. This association was independent of age, severity of illness, presence or absence of sepsis, and treatment allocation.
conclusionsGenetic variants in thrombomodulin and endothelial protein C receptor genes are additively associated with mortality in ARDS. These findings suggest that genetic differences may be at least partially responsible for the observed associations between dysregulated coagulation and poor outcomes in ARDS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.