ArticleJournal of clinical research in pediatric endocrinology2016
Luteinizing Hormone Secretion during Gonadotropin-Releasing Hormone Stimulation Tests in Obese Girls with Central Precocious Puberty.
Article in Journal of clinical research in pediatric endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Interpreting the GnRH stimulation test in girls with central precocious puberty: the role of age and body mass index.Journal of endocrinological investigation · 2026Article
- Serum inflammatory and metabolic signatures accelerate precocious puberty in obese children.Pediatric research · 2026Article
- Preventive Effects ofInternational journal of molecular sciences · 2025Article
- Central precocious puberty in boys; diagnosis, treatment and follow-up: a nation-wide study.Endocrine · 2025Article
- The value of urinary gonadotropin after triptorelin stimulation tests for diagnosing central precocious puberty in girls with overweight or obesity: a single-center study.BMC pediatrics · 2025Article
- The effect of obesity on the GnRH stimulation test in girls with idiopathic central precocious puberty.European journal of pediatrics · 2025Article
- A single blood luteinizing hormone level of triptorelin stimulation test can diagnose hypothalamic-pituitary-gonadal axis activation in girls with high body mass index.Frontiers in pediatrics · 2025Article
- [Value of single-phase gonadotropin-releasing hormone stimulation test in diagnosis of central precocious puberty in girls with different levels of body mass index].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Long-term efficacy of a triptorelin 3-month depot in girls with central precocious puberty.Annals of pediatric endocrinology & metabolism · 2024Article
- Changes in blood glucose and lipid metabolism levels in children with central precocious puberty and its correlation with obesity.Frontiers in pediatrics · 2024Article
- Central precocious puberty: is routine brain MRI screening necessary for girls?: Commentary on "Brain magnetic resonance imaging (MRI) findings in central precocious puberty patients: is routine MRI necessary for newly diagnosed patients?"Annals of pediatric endocrinology & metabolism · 2023Article
- Article
- Relationship between Body Mass Index and Bone Turnover Markers in Girls with Idiopathic Central Precocious Puberty.International journal of clinical practice · 2023Article
- An Approach to the Evaluation and Management of the Obese Child With Early Puberty.Journal of the Endocrine Society · 2022Review
- Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in precocious puberty: a mini review.Annals of pediatric endocrinology & metabolism · 2020Article
- Basal serum luteinizing hormone value as the screening biomarker in female central precocious puberty.Annals of pediatric endocrinology & metabolism · 2019Article
- The effect of overweight on the luteinizing hormone level after gonadorelin stimulation test in girls with idiopathic central precocious puberty.Annals of pediatric endocrinology & metabolism · 2018Article
- Association between Body Mass Index and Serum Dehydroepiandrosterone Sulfate Level in 8-Year-Old Girls.Journal of obesity & metabolic syndrome · 2018Article
- Induction of Stress Signaling In Vitro and Suppression of Gonadotropin Secretion by Free Fatty Acids in Female Mouse Gonadotropes.Endocrinology · 2018Article
- High-Fat, High-Sugar Diet Disrupts the Preovulatory Hormone Surge and Induces Cystic Ovaries in Cycling Female Rats.Journal of the Endocrine Society · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveGirls with precocious puberty have high luteinizing hormone (LH) levels and advanced bone age. Obese children enter puberty at earlier ages than do non-obese children. We analyzed the effects of obesity on LH secretion during gonadotropin-releasing hormone (GnRH) tests in girls with precocious puberty.
methodsA total of 981 subjects with idiopathic precocious puberty who had undergone a GnRH stimulation testing between 2008 and 2014 were included in the study. Subjects were divided into three groups based on body mass index (BMI). Auxological data and gonadotropin levels after the GnRH stimulation test were compared.
resultsIn Tanner stage 2 girls, peak stimulated LH levels on GnRH test were 11.9±7.5, 10.4±6.4, and 9.1±6.1 IU/L among normal-weight, overweight, and obese subjects, respectively (p=0.035 for all comparisons). In Tanner stage 3 girls, peak stimulated LH levels were 14.9±10.9, 12.8±7.9, and 9.6±6.0 IU/L, respectively (p=0.022 for all comparisons). However, in Tanner stage 4 girls, peak stimulated LH levels were not significantly different among normal, overweight, and obese children. On multivariate analysis, BMI standard deviation score was significantly and negatively associated with peak LH (β=-1.178, p=0.001).
conclusionIn girls with central precocious puberty, increased BMI was associated with slightly lower peak stimulated LH levels at early pubertal stages (Tanner stages 2 and 3). This association was not valid in Tanner stage 4 girls.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.