ArticleThe EMBO journal1989
Interaction of nuclear factors with the upstream region of the alpha-subunit gene of chicken muscle acetylcholine receptor: variations with muscle differentiation and denervation.
Article in The EMBO journal, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Comparing the epigenetic landscape in myonuclei purified with a PCM1 antibody from a fast/glycolytic and a slow/oxidative muscle.PLoS genetics · 2021Article
- An acetylcholine receptor alpha subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis.The Journal of clinical investigation · 1998Article
- Transcription enhancer factor 1 interacts with a basic helix-loop-helix zipper protein, Max, for positive regulation of cardiac alpha-myosin heavy-chain gene expression.Molecular and cellular biology · 1997Article
- Novel muscle-specific enhancer sequences upstream of the cardiac actin gene.Molecular and cellular biology · 1994Article
- In vivo and in vitro analysis of electrical activity-dependent expression of muscle acetylcholine receptor genes using adenovirus.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Chicken neuronal acetylcholine receptor alpha 2-subunit gene exhibits neuron-specific expression in the brain and spinal cord of transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Muscle-specific expression of the acetylcholine receptor alpha-subunit gene requires both positive and negative interactions between myogenic factors, Sp1 and GBF factors.The EMBO journal · 1993Article
- Differential expression of human nicotinic acetylcholine receptor alpha subunit variants in muscle and non-muscle tissues.Nucleic acids research · 1993Article
- Regulation of the mouse desmin gene: transactivated by MyoD, myogenin, MRF4 and Myf5.Nucleic acids research · 1993Article
- Characterization of an enhancer upstream from the muscle-type promoter of a gene encoding 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.Nucleic acids research · 1992Article
- Analysis of binding and activating functions of the chick muscle acetylcholine receptor gamma-subunit upstream sequence.Cellular and molecular neurobiology · 1992Article
- The 5'-flanking region of the mouse muscle nicotinic acetylcholine receptor beta subunit gene promotes expression in cultured muscle cells and is activated by MRF4, myogenin and myoD.Nucleic acids research · 1992Article
- An acetylcholine receptor alpha-subunit promoter conferring preferential synaptic expression in muscle of transgenic mice.The EMBO journal · 1991Article
- Muscle-specific expression of the troponin I gene requires interactions between helix-loop-helix muscle regulatory factors and ubiquitous transcription factors.Molecular and cellular biology · 1991Article
- Expression of the acetylcholine receptor delta-subunit gene in differentiating chick muscle cells is activated by an element that contains two 16 bp copies of a segment of the alpha-subunit enhancer.The EMBO journal · 1990Article
- Induction of acetylcholine receptor alpha-subunit gene expression in chicken myotubes by blocking electrical activity requires ongoing protein synthesis.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.Molecular and cellular biology · 1989Article
- Ligand-gated ion channels. Homology and diversity.Molecular neurobiologyReview
- Activity-dependent regulation of gene expression in muscle and neuronal cells.Molecular neurobiologyReview
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3 authors.
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Abstract
The region lying between nucleotides (nt) -110 and -45 of chicken acetylcholine receptor alpha-subunit gene 5' upstream sequence confers developmental control of expression in primary cultures of chicken myotubes. This region interacts with several nuclear factors present in muscle cells as shown by DNase I footprinting and gel-retardation experiments. An Sp1-like factor and a guanine stretch-binding protein were found to bind to overlapping sites immediately upstream of the TATA box. Several factors interacting in the same region with a domain similar to the SV40 enhancer core appeared during in vitro differentiation of myoblasts into myotubes. The concentration of some of these factors increased also after denervation of leg muscle in newborn chickens. The specific interaction of nuclear factors with this domain may thus play a critical role in the regulation of alpha-subunit gene expression by muscle differentiation and electrical activity.
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