ArticleMovement disorders : official journal of the Movement Disorder Society2016
Tractography-Based Ventral Intermediate Nucleus Targeting: Novel Methodology and Intraoperative Validation.
Article in Movement disorders : official journal of the Movement Disorder Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.
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Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The research focus and frontiers in surgical treatment of essential tremor.Frontiers in neurology · 2024Pooled it
- Outcome and Complications of MR Guided Focused Ultrasound for Essential Tremor: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Directed stimulation of the dentato-rubro-thalamic tract for deep brain stimulation in essential tremor: a blinded clinical trial.The neuroradiology journal · 2022Trial
- Gamma knife thalamotomy for essential tremor in the third era of functional neurosurgery.Neurosurgical review · 2026Observational
- Focused Ultrasound Ablation for Neurological Disorders.Biological psychiatry · 2026Review
- Advanced MRI for targeting the pallidothalamic region in magnetic resonance-guided focused ultrasound: the mammillothalamic tract as an adjacent imaging landmark.Frontiers in radiology · 2026Review
- Personalized tremor control targeting for MR-guided focused ultrasound using tractography.Brain communications · 2026Article
- Multimodal Imaging to Support Vim Targeting in Magnetic Resonance-Guided Focused Ultrasound Thalamotomy: Two Technically and Anatomically Challenging Cases.NMC case report journal · 2026Article
- How accurate is probabilistic tractography when used to predict the "sweet spot" in deep brain stimulation? Mind the gap!Acta neurochirurgica · 2025Article
- The Results of a 12-Month Open-Label Follow-Up Study with MRI Monitoring of Patients with Parkinson's Disease After MRI-Guided FUS.Journal of clinical medicine · 2025Article
- Deep Brain Stimulation for Parkinson's Disease-A Narrative Review.Biomedicines · 2025Review
- The Modern Utility of Awake Deep Brain Stimulation Surgery.medRxiv : the preprint server for health sciences · 2025Article
- Optimal focused ultrasound lesion location in essential tremor.Science advances · 2025Article
- Predicting Post-Operative Side Effects in VIM MRgFUS Based on THalamus Optimized Multi Atlas Segmentation (THOMAS) on White-Matter-Nulled MRI: A Retrospective Study.AJNR. American journal of neuroradiology · 2025Article
- An image quality transfer approach for localising deep brain stimulation targets.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Awake versus asleep deep brain stimulation targeting the caudal zona incerta for essential tremor.NPJ Parkinson's disease · 2024Article
- The Use of Focused Ultrasound Ablation for Movement Disorders.Magnetic resonance imaging clinics of North America · 2024Review
- Four-tract probabilistic tractography technique for target selection in essential tremor treatment with magnetic resonance-guided focused ultrasound.European radiology · 2024Article
- Quantitative susceptibility mapping and a nonlinearly transformed atlas for targeting the ventral intermediate nucleus of the thalamus in a patient with tremor and thalamic hypertrophy: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- The role of the motor thalamus in deep brain stimulation for essential tremor.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
4 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
backgroundThe ventral intermediate nucleus of the thalamus is not readily visible on structural magnetic resonance imaging. Therefore, a method for its visualization for stereotactic targeting is desirable.
objectiveThe objective of this study was to define a tractography-based methodology for the stereotactic targeting of the ventral intermediate nucleus.
methodsThe lateral and posterior borders of the ventral intermediate nucleus were defined by tracking the pyramidal tract and medial lemniscus, respectively. A thalamic seed was then created 3 mm medial and anterior to these borders, and its structural connections were analyzed. The application of this method was assessed in an imaging cohort of 14 tremor patients and 15 healthy controls, in which we compared the tractography-based targeting to conventional targeting. In a separate surgical cohort (3 tremor and 3 tremor-dominant Parkinson's disease patients), we analyzed the accuracy of this method by correlating it with intraoperative neurophysiology.
resultsTractography of the thalamic seed revealed the tracts corresponding to cerebellar input and motor cortical output fibers. The tractography-based target was more lateral (12.5 [1.2] mm vs 11.5 mm for conventional targeting) and anterior (8.5 [1.1] mm vs 6.7 [0.3] mm, anterior to the posterior commissure). In the surgical cohort, the Euclidian distance between the ventral intermediate nucleus identified by tractography and the surgical target was 1.6 [1.1] mm. The locations of the sensory thalamus, lemniscus, and pyramidal tracts were concordant within <1 mm between tractography and neurophysiology.
interpretationThe tractography-based methodology for identification of the ventral intermediate nucleus is accurate and useful. This method may be used to improve stereotactic targeting in functional neurosurgery procedures. © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
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