ArticleJournal of veterinary internal medicine2016
Thymidine Kinase Type 1 and C-Reactive Protein Concentrations in Dogs with Spontaneously Occurring Cancer.
Article in Journal of veterinary internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Thromboembolic disease and hemostatic alterations in tumor-bearing dogs - A narrative review.Frontiers in veterinary science · 2026Review
- OncoCan: a liquid biopsy assay for cell-free DNA quantification in canine plasma to support cancer prognosis.Frontiers in veterinary science · 2026Article
- Beyond Individual Acute Phase Protein Assessments: Introducing the Acute Phase Index (API) as a Prognostic Indicator in Dogs with Malignant Neoplasia.Veterinary sciences · 2025Article
- Diagnostic value of serum survivin, Ki-67 and thymidine kinase in dogs with nasal cavity disease.Frontiers in veterinary science · 2025Article
- A novel cross-validated machine learning based Alertix-Cancer Risk Index for early detection of canine malignancies.Frontiers in veterinary science · 2025Article
- Evaluation of Serum YKL-40 in Canine Multicentric Lymphoma: Clinical and Diagnostic Implications.Animals : an open access journal from MDPI · 2024Article
- CA 15-3, CRP, and LDH correlates with prognostic parameters in canine mammary neoplasms.Animal reproduction · 2023Article
- A monoclonal antibody-based sandwich ELISA for measuring canine Thymidine kinase 1 protein and its role as biomarker in canine lymphoma.Frontiers in veterinary science · 2023Article
- Blood biomarkers for canine cancer, from human to veterinary oncology.Veterinary and comparative oncology · 2022Review
- Impact of serum C-reactive protein level as a biomarker of cancer dissemination in canine lymphoid neoplasia.Veterinary world · 2022Article
- Serum concentrations of canine pancreatic lipase immunoreactivity and C-reactive protein for monitoring disease progression in dogs with acute pancreatitis.Journal of veterinary internal medicine · 2021Article
- Serum C-reactive protein in dogs with paraplegia secondary to acute intervertebral disc extrusion.Journal of veterinary internal medicine · 2021Article
- Characterizing circulating nucleosomes in the plasma of dogs with hemangiosarcoma.BMC veterinary research · 2021Article
- Horizons in Veterinary Precision Oncology: Fundamentals of Cancer Genomics and Applications of Liquid Biopsy for the Detection, Characterization, and Management of Cancer in Dogs.Frontiers in veterinary science · 2021Review
- Thymidine kinase 1 through the ages: a comprehensive review.Cell & bioscience · 2020Review
- Primary Adenosquamous Cell Carcinoma of the Ileum in a Dog.Veterinary sciences · 2020Article
- Extracellular cyclic adenosine monophosphate-dependent protein kinase A autoantibody and C-reactive protein as serum biomarkers for diagnosis of cancer in dogs.Veterinary and comparative oncology · 2019Article
- The Current State of Clinical Application of Serum Biomarkers for Canine Lymphoma.Frontiers in veterinary science · 2016Review
- Serum thymidine kinase 1 protein concentrations and presence of its autoantibody as biomarkers for screening dogs with malignant tumors.Journal of veterinary internal medicineArticle
- Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C-reactive protein for early detection of malignant tumors in dogs.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerum thymidine kinase type 1 (TK1) and canine C-Reactive Protein (cCRP) might be useful in detecting dogs with cancer. Algorithms combining biomarkers are sometimes more accurate than results of individual tests.
objectivesThe aim of this study was to compare serum TK1 and cCRP and Neoplasia Index (NI) in healthy and tumor-bearing dogs. ANIMALS: Client-owned dogs with (n = 253) and without (n = 156) cancer.
methodsRetrospective case-control study. Dogs with cancer were identified after submission of samples for commercial assay and case details were retrospectively collected. Healthy dogs (control) were identified through breed groups and health status was confirmed by health questionnaire for a minimum of 6 months. Serum TK1 activity was measured using a quantitative chemiluminescent assay and serum cCRP was measured using a quantitative ELISA assay.
resultsTK1 activity in the cancer (n = 253) and control group (n = 156) were 7.0 μ/L (median, range <0.5 to >100) and 1.8 μ/L (median, range 0.4 to 55.3), respectively (P < .001). cCRP concentrations in the cancer and control group were 6.0 mg/L (median, range <0.5 to >50) and 1.6 mg/L (median, range 0.09 to >50), respectively (P < .001). The NI in the cancer and control group were 6.4 (median, range 0-9.9) and 0.9 (median, range 0-7.6), respectively (P < .001). ROC AUCs of the NI and TK1 for all cancers were greater than 0.8, highest for lymphoma and histiocytic sarcoma. CONCLUSIONS AND CLINICAL IMPORTANCE: Increased concentrations of TK1 and cCRP, when present in dogs with cancer, might be useful in confirming a diagnosis and monitoring response to treatment.
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